Tag Archives: Australia Scientific research

New biosecurity centre to stop fruit flies

Upgraded bio-security measures to combat fruit fly will be introduced in Australia, bringing added confidence to international trade markets.

South Australia is the only mainland state in Australia that is free from fruit flies – a critical component of the horticultural industries’ successful and expanding international export market.

A new national Sterile Insect Technology facility in Port Augusta, located in the north of South Australia, will produce billions of sterile male fruit flies – at the rate of 50 million a week – to help prevent the threat of fruit fly invading the state.

The new measures will help secure producers’ access to important citrus and almond export markets including the United States, New Zealand and Japan, worth more than $800 million this year.

The Sterile Insect Technique (SIT) introduces sterile flies into the environment that then mate with the wild population, ensuring offspring are not produced.

Macquarie University Associate Professor Phil Taylor says the fly, know as Qfly because they come from Queensland, presents the most difficult and costly biosecurity challenge to market access for most Australian fruit producers.

“Fruit flies, especially the Queensland fruity fly, present a truly monumental challenge to horticultural production in Australia,” he says.

“For generations, Australia has relied on synthetic insecticides to protect crops, but these are now banned for many uses. Environmentally benign alternatives are needed urgently – this is our goal.

The impetus behind this initiative is to secure and improve trade access both internationally and nationally for South Australia.

It will increase the confidence of overseas buyers in the Australian product and make Australia a more reliable supplier. Uncertainty or variation of quality of produce would obviously be a concern for our trading partners.”

South Australia’s Agriculture Minister Leon Bignell says the $3.8 million centre would produce up to 50 million sterile male Qflies each week.

“The State Government has invested $3 million and Horticulture Innovation Australia Ltd (HIA) has contributed $800,000 in this project and construction is expected to take 10 months,” Bignell says.

“While fruit fly is a major problem with horticultural crops in Australia’s other mainland states, South Australia remains fruit fly free, but we are still at risk of outbreak.”

“Producing male-only sterile Qflies has never been done before on this scale and this facility will have an enormous impact on the way in which we deal with outbreaks.”

Fruit fly management protects the commercial production of fruit and vegetables, including wine grapes and almonds, with an estimated farm-gate value of $851 million.

South Australia is also the only mainland state which has a moratorium on growing GM food crops and is one of the few places in the world free of the vine-destroying pest phylloxera.

“Because of these attributes, South Australian products stand out in the competitive global market, which is increasingly seeking clean and safe food and wine,” Bignell says.

The research partner consortium, SITplus, intends to invest about $50 million during the next five years to support the national fruit fly management program.

The consortium is a research group with experts from Macquarie University, Primary Industries and Regions SA’s Biosecurity SA and South Australian Research and Development Institute divisions, HIA, the CSIRO Health and Biosecurity Flagship, Plant & Food Research Australia, and the NSW Department of Primary Industries.

– John Merriman

This article was first published by The Lead South Australia on 2 September 2015. Read the original article here.

L’Oreal-UNESCO for Women in Science Fellow 2015

A passion for fish and sharks, and a desire to better understand how climate change will have an impact on marine species has seen Townsville-based scientist, Dr Jodie Rummer win one of the prestigious Australia L’Oreal-UNESCO For Women in Science Fellowships for 2015.

Dr Rummer, a marine biologist with the ARC Centre of Excellence for Coral Reef Studies at James Cook University, is one of four scientists from Australia and New Zealand to be recognised with the highly competitive award.

Dr Jodie Rummer examines an epaulette shark. Photo: Richard Davis, JCU Media.

Dr Jodie Rummer examines an epaulette shark. Photo: Richard Davis, JCU Media.

The Fellowship provides $25,000 to support recipients with their research and foster the careers of female scientists.

Rummer says she is honoured to receive the award, which will help support her work on predicting how sharks and other fish will cope with rapidly changing oceans.

“Fish have been evolutionary winners, but we don’t know how they will adapt with the rapid changes taking place in the oceans now.

Some will be winners, some will be losers as the climate changes, and that’s a problem not just for the oceans, but also for the communities that depend on fish for protein.

Fish have been on the planet for hundreds of millions of years. It’s up to us to ensure they’re here for the next 100 million years.”

Rummer’s research examines how ‘oxygen transport’ works in fish and how it is affected by stress and their ability to adapt to their habitats.

To get a better understanding of the capacity of fish to adapt, Rummer is working with sharks on the Great Barrier Reef, in Papua New Guinea, and in French Polynesia.

Her L’Oréal-UNESCO For Women in Science Fellowship will help expand her work in the world’s largest shark sanctuary in Moorea, French Polynesia.

There she will study sicklefin lemon and black-tip reef sharks, which may be less able to adapt to future ocean conditions.

“In the long term, understanding how sharks will respond to future ocean conditions will help us make wise decisions needed to protect and conserve the world’s fish populations in general,” Rummer says.

Rummer’s work has attracted global scientific and media attention. She is also a strong advocate for improving the status of women in science.

Rummer is a Research Fellow at the ARC Centre of Excellence for Coral Reef Studies at James Cook University, where she holds an Australian Research Council Discovery Early Career Research Award (ARC DECRA).


A hot future for sharks

Dr Jodie Rummer, marine biologist, James Cook University, Townsville

Dr Jodie Rummer is fascinated by fish and their ability to deliver oxygen to their muscles 20 to 50 times more efficiently than we can. Her global research into salmon, mackerel, hagfish, and now sharks explains why fish dominate the oceans, and has given her the opportunity to swim with sharks in the world’ largest shark sanctuary, in French Polynesia.


This article was first published by James Cook University on 8 September 2015. Read the original article here.

 

Mosquito urban wetlands

After a stint working as an environmental consultant trawling swampland in Sydney and Wollongong, Jayne Hanford has gone back to uni to do a postgrad researching one of Australia’s least favourite invertebrates – mosquitoes.

“Bugs are really cool,” says Jayne, with characteristic enthusiasm. “They’re like little aliens when you look at them under a microscope, and there’s a lot of diversity.”

Jayne’s research at The University of Sydney looks at what conditions can create mosquito-free urban wetlands and preserve urban wetland biodiversity.

“I’m the only person researching the aquatic environment – there are people working on tic pathogens, bees, spiders, ants and bats in urban areas,” says Jayne, describing the diversity of research being undertaken at her lab.

There is currently little research on biodiversity in urban wetlands – and what research is available is somewhat disjointed.

While the conditions conducive for mosquitoes are well understood in natural wetlands, as are the conditions for creating high biodiversity, these findings haven’t been applied to urban wetland ecology.

“I hadn’t really thought about mosquitoes before, I was more interested in the protection of biodiversity, and thought it would be interesting to look at that in an urban context,” says Jayne.

Her main supervisor at the uni, Associate Professor Dieter Hochuli is focused on urban ecology, so Jayne took the opportunity to undertake research into how biodiversity and mosquito populations are linked in urban wetlands.

“The councils I’ve spoken to would really like to know if their wetlands do have mosquitoes because it influences how they manage them in the future.”

As wetland vegetation are often good breeding grounds for mosquitoes, Jayne’s research will assist councils to understand the biodiversity value of a wetland and whether it poses a risk to public health from mosquito-borne diseases.

This understanding will lead to better management of a wetland’s biodiversity while minimising risks from mosquitos. And could allow for the integration of biodiversity and stormwater and wastewater management strategies with public health programs.

“My research will look at what we need to create a really good network of wetlands for conservation in urban areas that tick all the boxes,” explains Jayne.

“They must be visually appealing, be places for recreation, provide a habitat for wildlife, improve water quality, minimise mosquito or weed infestations – and avoid making people sick. People can walk their dogs around them, and they benefit biodiversity.”

– Carl Williams

Southern stars: the decade ahead for Australian astronomy

Extremely large optical telescopes, including the Giant Magellan Telescope (GMT), which is due to be built in Chile in 2021, will allow studies of stars and galaxies at the dawn of the universe, and will peer at planets similar to ours around distant stars.

The Square Kilometer Array (SKA), which will be constructed in Australia and South Africa over the next several years, will observe the transformation in the young universe that followed the formation of the first generation of stars and test Einstein’s theory of relativity.

Large-scale surveys of stars and galaxies will help us discover how elements are produced and recycled through galaxies to enrich the universe. The revolutionary sensitivity of the GMT will also be used to understand the properties of ancient stars born at the dawn of the universe.

In the coming decade, astronomers will also learn how galaxies evolve across cosmic time through new coordinated Australian-led surveys using the Australian SKA Pathfinder, the Australian Astronomical Observatory and next-generation optical telescopes.

On the largest scales, dark matter and dark energy comprise more than 95% of the universe, and yet their nature is still unknown. Australian astronomers will use next-generation optical telescopes to measure the growth of the universe and probe the unknown nature of dark matter and dark energy.

The long-anticipated detection of gravitational waves will also open a window into the most extreme environments in the universe. The hope is that gravitational waves generated by the collision of black holes will help us better understand the behavior of matter and gravity at extreme densities.

Closer to home, the processes by which interstellar gas is turned into stars and solar systems are core to understanding our very existence. By combining theoretical simulations with observations from the Australia Telescope Compact Array and the GMT, Australian astronomers will discover how stars and planets form.

And this far-reaching knowledge will inform new theoretical models to achieve an unprecedented understanding of the universe around us.


Australia’s role

These are some of the exciting projects highlighted in the latest decadal plan for Australian astronomy, which was launched at Parliament House on Wednesday August 12.

Over the past decade, Australian astronomers have achieved a range of major breakthroughs in optical and radio astronomy and in theoretical astrophysics.

Star trails above one of Australia’s great telescopes at Siding Spring Observatory. Australian Astronomical Observatory/David Malin

Star trails above one of Australia’s great telescopes at Siding Spring Observatory. Australian Astronomical Observatory/David Malin

Australian astronomers have precisely measured the properties of stars, galaxies and of the universe, significantly advancing our understanding of the cosmos. The mass, geometry, and expansion of the universe have been measured to exquisite accuracy using giant surveys of galaxies and exploding stars. Planetary astronomy has undergone a revolution, with the number of planets discovered around other stars now counted in the thousands.

In forming a strategy for the future, Australia in the Era of Global Astronomy assesses these and other scientific successes, as well as the evolution of Australian astronomy including it’s broader societal roles.

Astronomy is traditionally a vehicle for attracting students into science, technology, engineering and mathematics (STEM). The report also highlights expanding the use of astronomy to help improve the standard of science education in schools through teacher-training programs.

Training aimed at improving the “transferrable” skills of graduate and postgraduate astronomy students will also help Australia improve its capacity for innovation.


Look far

The Australian astronomy community has greatly increased its capacity in training of higher-degree students and early-career researchers. However, Australian astronomy must address the low level of female participation among its workforce, which has remained at 20% over the past decade.

The past decade has seen a large rise in Australian scientific impact from international facilities. This move represents a watershed in Australian astronomical history and must be strategically managed to maintain Australia’s pre-eminent role as an astronomical nation.

The engagement of industry will become increasingly important in the coming decade as the focus of the scientific community moves from Australian-based facilities, which have often been designed and built domestically, towards new global mega-projects such as the SKA.

While a decade is an appropriate timescale on which to revisit strategic planning across the community, the vision outlined in the plan looked beyond the past decade, recommending far-reaching investments in multi-decade global projects such as the GMT and the SKA.

These recent long-term investments will come to fruition in the coming decade, positioning Australia to continue as a global astronomy leader in the future.

This article was first published by The Conversation on 24 August 2015. Read the original article here.

Building power by concentrating light

South Australian company HeliostatSA has partnered with Indian company Global Wind Power Limited to develop a portfolio of projects in India and Australia over the next four years. It will begin with an initial 150 megawatts in Concentrated Solar Powered (CSP) electricity in Rajashtan, Indian using a solar array.

The projects are valued at $2.5 billion and will further cement HeliostatSA as a leader in the global renewable energy sector.

Heliostat CEO Jason May says India had made a commitment to reaching an investment target of USD $100 billion of renewable energy by 2019 and has already secured $20 billion.

“India is looking for credible, renewable energy partners for utility scale projects,’’ says May.

“We bring everything to the table that they require such as size, project development experience, capital funding, field design capability, the latest technology, precision manufacturing and expertise.’’

Each solar array is made of thousands of heliostats, which are mirrors that track and reflect the suns thermal energy on to a central receiver. The energy is then converted into electricity. Each HeliostatSA mirror is 3.21 x 2.22 metres with optical efficiency believed to be the most accurate in the world. This reduces the number of mirrors required, reducing the overall cost of CSP while still delivering the same 24-hour electricity outputs.

The heliostats and their high tech components are fabricated using laser mapping and steel cutting technology.

The mirrors are slightly parabolic and components need to be cut and measured to exact requirements to achieve the strict operational performance.

“There is strong global interest in CSP with thermal storage for 24-hour power. At the moment large-scale batteries which also store electricity are very expensive. Constant advances in CSP storage technology over the next 10 years will only add to the competitive advantage,’’ says May.

– John Merriman

This article was first published by The Lead South Australia on 25 August 2015. Read the original article here.

Work on barren soil may bear fruit

Australian and Chinese scientists have made significant progress in determining what causes soil acidification – a discovery that could assist in turning back the clock on degraded croplands.

James Cook University’s Associate Professor Paul Nelson says the Chinese Academy of Sciences sought out the Australian researchers because of work they had done in Australia and Papua New Guinea on the relationship between soil pH levels and the management practices that cause acidification.

Professor Paul Nelson at work.

Professor Paul Nelson at work.

Building on the JCU work, scientists examined a massive 3600 km transect of land in China, stretching from the country’s sub-arctic north to its central deserts. The work yielded a new advance that describes the mechanisms involved in soils becoming acidified.

Nelson says soil degradation is a critical problem confronting humanity, particularly in parts of the world such as the tropics where land use pressure is increasing and the climate is changing. “We can now quantify the effect of, for instance, shutting down a factory that contributes to the production of acid rain,” he says.

Nelson says the research found different drivers of soil acidification processes in different types of soil across northern China. “This information is vital for designing strategies that prevent or reverse soil acidification and to help land managers tailor their practices to maintain or improve soil quality,” he says.

The Patron of Soil Science Australia, former Australian Ambassador to the United Nations and for the Environment, The Honourable Penny Wensley AC, welcomed news of the advance.

“With 2015 designated by the United Nations as the International Year of Soils, this is a very important year for soil scientists around the world. We need to promote greater awareness of the importance of soils and soil health and the role soil science has to play in addressing national and global challenges.”

In the context of the International Year of Soils, Wensley says: “We want to encourage greater cooperation and exchanges between soil scientists, to accelerate progress in research and achieve outcomes that will deliver practical benefits to farmers and land managers, working in diverse environments.

“This research project, drawing on the shared expertise of soil scientists from Australia’s James Cook University and the Chinese Academy of Sciences, is an exciting illustration of what can be achieved through greater collaboration,” she says.

Acidification is one of the main soil degradation issues worldwide, accelerated by water leaching through the soil. It is related mostly to climate, and the overuse of nitrogen-based fertiliser.

“The greater understanding of soil acidification causes this study has delivered could help improve soil management practices, not only in Australia and China, but around the world,” says Wensley.

The study has been published in the journal, Biogeosciences.

This article was first published by James Cook University on 19 August 2015. Read the original article here.

From science fiction to reality: the dawn of the biofabricator

 

“We can rebuild him. We have the technology.”
– The Six Million Dollar Man, 1973

Science is catching up to science fiction. Last year a paralysed man walked again after cell treatment bridged a gap in his spinal cord. Dozens of people have had bionic eyes implanted, and it may also be possible to augment them to see into the infra-red or ultra-violet. Amputees can control bionic limb implant with thoughts alone.

Meanwhile, we are well on the road to printing body parts.

We are witnessing a reshaping of the clinical landscape wrought by the tools of technology. The transition is giving rise to a new breed of engineer, one trained to bridge the gap between engineering on one side and biology on the other.

Enter the “biofabricator”. This is a role that melds technical skills in materials, mechatronics and biology with the clinical sciences.


21st century career

If you need a new body part, it’s the role of the biofabricator to build it for you. The concepts are new, the technology is groundbreaking. And the job description? It’s still being written.

It is a vocation that’s already taking off in the US though. In 2012, Forbes rated biomedical engineering (equivalent to biofabricator) number one on its list of the 15 most valuable college majors. The following year, CNN and payscale.com called it the “best job in America”.

These conclusions were based on things like salary, job satisfaction and job prospects, with the US Bureau of Labour Statistics projecting a massive growth in the number of biomedical engineering jobs over the next ten years.

Meanwhile, Australia is blazing its own trail. As the birthplace of the multi-channel Cochlear implant, Australia already boasts a worldwide reputation in biomedical implants. Recent clinical breakthroughs with an implanted titanium heel and jawbone reinforce Australia’s status as a leader in the field.

The Cochlear implant has brought hearing to many people. Dick Sijtsma/Flickr, CC BY-NC

The Cochlear implant has brought hearing to many people. Dick Sijtsma/Flickr, CC BY-NC

I’ve recently helped establish the world’s first international Masters courses for biofabrication, ready to arm the next generation of biofabricators with the diverse array of skills needed to 3D print parts for bodies.

These skills go beyond the technical; the job also requires the ability to communicate with regulators and work alongside clinicians. The emerging industry is challenging existing business models.


Life as a biofabricator

Day to day, the biofabricator is a vital cog in the research machine. They work with clinicians to create a solution to clinical needs, and with biologists, materials and mechatronic engineers to deliver them.

Biofabricators are naturally versatile. They are able to discuss clinical needs pre-dawn, device physics with an electrical engineer in the morning, stem cell differentiation with a biologist in the afternoon and a potential financier in the evening. Not to mention remaining conscious of regulatory matters and social engagement.

Our research at the ARC Centre of Excellence for Electromaterials Science (ACES) is only made possible through the work of a talented team of biofabricators. They help with the conduits we are building to regrow severed nerves, to the electrical implant designed to sense an imminent epileptic seizure and stop it before it occurs, to the 3D printed cartilage and bone implants fashioned to be a perfect fit at the site of injury.

As the interdisciplinary network takes shape, we see more applications every week. Researchers have only scratched the surface of what is possible for wearable or implanted sensors to keep tabs on an outpatient’s vitals and beam them back to the doctor.

Meanwhile, stem cell technology is developing rapidly. Developing the cells into tissues and organs will require prearrangement of cells in appropriate 3D environments and custom designed bioreactors mimicking the dynamic environment inside the body.

Imagine the ability to arrange stem cells in 3D surrounded by other supporting cells and with growth factors distributed with exquisite precision throughout the structure, and to systematically probe the effect of those arrangements on biological processes. Well, it can already be done.

Those versed in 3D bioprinting will enable these fundamental explorations.


Future visions

Besides academic research, biofabricators will also be invaluable to medical device companies in designing new products and treatments. Those engineers with an entrepreneurial spark will look to start spin-out companies of their own. The more traditional manufacturing business model will not cut it.

As 3D printing evolves, it is becoming obvious that we will require dedicated printing systems for particular clinical applications. The printer in the surgery for cartilage regeneration will be specifically engineered for the task at hand, with only critical variables built into a robust and reliable machine.

The 1970s TV show, Six Million Dollar Man, excited imaginations, but science is rapidly catching up to science fiction. Joe Haupt/Flickr, CC BY-SA

The 1970s TV show, Six Million Dollar Man, excited imaginations, but science is rapidly catching up to science fiction. Joe Haupt/Flickr, CC BY-SA

Appropriately trained individuals will also find roles in the public service, ideally in regulatory bodies or community engagement.

For this job of tomorrow, we must train today and new opportunities are emerging biofab-masters-degree. We must cut across the traditional academic boundaries that slow down such advances. We must engage with the community of traditional manufacturers that have skills that can be built upon for next generation industries.

Australia is also well placed to capitalise on these emerging industries. We have a traditional manufacturing sector that is currently in flux, an extensive advanced materials knowledge base built over decades, a dynamic additive fabrication skills base and a growing alternative business model environment.

– Gordon Wallace & Cathal D. O’Connell

This article was first published by The Conversation on 31 August 2015. Read the original article here.

Design innovations are blowing in the wind

RMIT researchers are using state-of-the-art modelling techniques to study the effects of wind on cities, paving the way for design innovations in building, energy harvesting and drone technology.

The turbulence modelling studies will allow engineers to optimise the shape of buildings, as well as identify areas of rapid airflow within cities that could be used to harvest energy.

Researchers also hope to use the airflow studies to develop more energy efficient drones that use the power of updrafts during flight.

Dr Abdulghani Mohamed, from RMIT’s Unmanned Aircraft Systems research group, said simulations developed by the research team can visualise the shape of updrafts as they developed over buildings and show their variation over time.

“By analysing the interaction of wind with buildings, our research opens new possibilities for improving designs to take better advantage of nature,” he says.

“Buildings can be built to enhance airflow at street level and ventilation, while wind turbines can be precisely positioned in high-speed airflow areas for urban energy harvesting – providing free power for low-energy electronics.

“The airflow simulations will also help us further our work on energy harvesting for micro-sized drones, developing technology that can help them use updrafts to gain height quicker and fly for longer, without using extra energy.”

Scientists and engineers have traditionally relied on building small-scale city replicas and testing them in wind tunnels to make detailed airflow predictions.

This time-consuming and expensive process is being gradually replaced with numerical flow simulations, also known as Computational Fluid Dynamics (CFD).

The researchers – Mohamed, Professor Simon Watkins (RMIT), Dr Robert Carrese (LEAP Australia) and Professor David Fletcher (University of Sydney) – created a CFD model to accurately predict the highly complex and dynamic airflow field around buildings at RMIT’s Bundoora campus west, in Melbourne’s north.

The simulation was validated using a series of full and model-scale experiments, with the results published in the prestigious Journal of Wind Engineering and Industrial Aerodynamics.

The next stage in the research will involve an extensive flight test campaign to further prove the feasibility of the concept of long endurance micro-sized drones, for use in a number of industries including structural monitoring, land surveying, mobile temporary networks and pollution tracking.

This article was first published by RMIT University on 9 August 2015. Read the original article here.

Brain teaser: 3D-printed ’tissue’ to help combat disease

The brain is amazingly complex, with around 86 billion nerve cells. The challenge for researchers to create bench-top brain tissue from which they can learn about how the brain functions, is an extremely difficult one.

Researchers at the ARC Centre of Excellence for Electromaterials Science (ACES), based at UOW’s Innovation Campus, have taken a step closer to meeting this challenge, by developing a 3D-printed layered structure incorporating neural cells, that mimics the structure of brain tissue.

The value of bench-top brain tissue is huge. Pharmaceutical companies spend millions of dollars testing therapeutic drugs on animals, only to discover in human trials that the drug has an altogether different level of effectiveness. We’re not sure why, but the human brain differs distinctly from that of an animal.

A bench-top brain that accurately reflects actual brain tissue would be significant for researching not only the effect of drugs, but brain disorders like schizophrenia, and degenerative brain disease.

ACES Director and research author Professor Gordon Wallace (pictured above with Rodrigo Lozano and Elise Stewart) said that the breakthrough is significant progress in the quest to create a bench-top brain that will enable important insights into brain function, in addition to providing an experimental test bed for new drugs and electroceuticals.

“We are still a long way from printing a brain but the ability to arrange cells so as they form neuronal networks is a significant step forward,” says Wallace.

To create their six-layered structure, researchers developed a custom bio-ink containing naturally occurring carbohydrate materials. The custom materials have properties that allow accurate cell dispersion throughout the structure, whilst providing a rare level of protection to the cells.

The bio-ink is then optimised for 3D-printing, and developed for use in a standard cell culturing facility without the need for expensive bio-printing equipment.

The result is a layered structure like brain tissue, in which cells are accurately placed and remain in their designated layer.

“This study highlights the importance of integrating advances in 3D-printing, with those in materials science, to realise a biological outcome,” says Wallace.

“This paves the way for the use of more sophisticated printers to create structures with much finer resolution.”

The research, funded through Wallace’s Australian Laureate Fellowship, is published in Biomaterials

This article was first published on 3 August 2015 by the University of Wollongong. Read the original article here.

Test on chemo drugs predict side effects

A chemosensitivity test hopes to identify which chemo drugs will provide benefit and which may cause unwanted side effects for sarcoma cancer patients.

University of Western Australia’s School of Surgery researchers are currently comparing three methods to identify the most effective and reliable method to grow a patient’s tumour cells.

Co-lead researcher Dr Nicholas Calvert says sarcoma is a group of rare cancers arising from bone, muscle and cartilage.

“While they are rare, they can be very aggressive and early detection is vital to successful treatment, which can involve chemotherapy, radiotherapy, and surgical treatment,” he says.

Calvert says it is difficult to predict tumour responsiveness to chemotherapy because there are over 70 different types of sarcoma with significant variation in the genetic profile of cells within each type.

Chemotherapy in this area is generally guided by research on chemotherapy efficacy on a specific tumour type or those that are similar.

“So successfully predicting whether a patient’s tumour will be similar to another patient’s tumour of the same type is very difficult,” says Calvert.

“Especially given there are only around 1200 new cases per year which does not provide a large enough trial to test different chemotherapy regimens.”


Gene library and cell cultures methods considered

One of the methods under review involves researchers analysing DNA from tumour cells and comparing them to an international library of genes to identify whether they have any mutations that will help or prevent a chemotherapy drug from working.

Another method involves growing tumour cells in the lab and then exposing them to different chemotherapy drugs to see which kill the cells and at what dose.

Finally, mouse xenograft will be considered where tumour cells are grown in lab mice which are then subjected to different chemotherapy drugs to see which kill the cells and at what dose.

Calvert says once this pilot study is completed they will expand it to a national trial to identify which of these tests is effective and reliable to select chemotherapy drugs.

“If we can identify a test that will allow us to take a sample of tumour, and identify how it will respond to chemotherapy it will have significant benefit for not only those with sarcoma but also other cancers,” says Calvert.

He says this ‘personalised medicine’ approach aims to confirm a tumour will respond to an agent before it is even given, and avoid the significant and sometimes life-threatening side effects of some the chemotherapy agents.

Sarcoma has approximately 1200 new cases diagnosed each year in Australia and accounts for approximately 1% of all adult malignancies and 15% of paediatric malignancies.

– Teresa Belcher

This article was originally published on Science Network Western Australia. Read the original article here.

 

A new sunscreen made from fish slime and algae

Researchers have developed a new UV blocking material out of naturally occurring molecules found in algae and fish slime that can be used to make more effective sunscreen, bandages and contact lenses.

Organisms like algae and cyanobacteria have evolved to synthesise their own UV screening compounds, such as mycosporine-like amino acids (MAAs).

MAAs are commonly found in the creatures that eat algae and cyanobacteria as well – tropical fish like those found on the Great Barrier Reef accrue the material in their slime and eyes to protect themselves from harmful UV radiation.

“Mycosporines are present a little bit everywhere, in many types of organisms,” says Professor Vincent Bulone, co-author of the research paper and Director of the ARC Centre of Excellence in Plant Cell Walls at the University of Adelaide.

“We have attached these small UV absorbing molecules in a non-reversible manner to a polymer called chitosan, that you can extract from the shells of shrimp or crabs.”

The result is an all-natural UVA and UVB screening material. Thanks to the versatility of chitosan, it can be used in a cream for topical application, a transparent film for use in materials like bandages, or coated on objects like textiles and outdoor furniture to protect them from UV damage.

Current sunscreen formulas use a combination of materials in order to screen both UVA and UVB radiation, including some that can have a negative effect on health in the long-term, such as titanium dioxide.

“It outperforms some of the compounds that are already used on the market in terms of the UV absorption capacity. The good thing is that it’s completely natural. We’ve also tested them on cell cultures and know they are not toxic,”says Bulone.

“We know, under laboratory conditions, the MAAs have no harmful effects. So they can be used for wound healing dressings for instance. You don’t need to change that dressing as often and it facilitates the healing of the skin.”

The compound is also highly stable, even under high temperatures.

While chitosan is already widely used for many applications and easily extracted from crustacean waste products such as prawn shells, MAAs are more difficult to produce.

“Extracting it from algae would be a very expensive process, but it is possible to produce them by engineering bacteria. This has been since the early 90s. It’s not a cheap process, but it can be done.”

Bulone was recently installed as Director of the ARC Centre of Excellence in Plant Cell Walls at the University of Adelaide in South Australia.

“I’ve only started recently in South Australia. This work was done in my lab in Sweden. I still split my time, 70% in Adelaide and 30% in Sweden.”

Published in ACS Applied Materials & Interfaces, the research was undertaken with colleagues at Sweden’s Royal Institute of Technology. It also involved close collaboration with partners in Spain.

Bulone is actively developing new collaborations within Australia and internationally to develop new concepts leading to increased crop production and quality for nutrition as well as protection of crops against devastating fungal pathogens. These developments rely on his long-standing expertise in the biochemistry of carbohydrates from plant and fungal cell walls.

This article was first published by The Lead on 29 July 2015. Read the original article here.

Curtin University in NASA’s Orbit with new SSERVI deal

Greg Schmidt, Deputy Director of SSERVI and Director of international partnerships (left) and Yvonne Pendleton, Director of NASA’s Solar System Exploration Research Virtual Institute (SSERVI) (middle), join Professor Phil Bland, Principal Investigator at Curtin University in Perth, Australia (right), in signing an international agreement to share scientific and technological expertise in exploration science. Photo Credit: D. Morrison/NASA

NASA and Curtin University, located in Perth, Western Australia, have signed an Affiliate Member statement with NASA’s Solar System Exploration Research Virtual Institute (SSERVI). With the establishment of a NASA SSERVI Australia node, Australia’s planetary science community will participate in SSERVI programs on a no-exchange-of-funds basis.

“Australia’s impressive proposal to SSERVI offers scientific and technological expertise in understanding Solar System origins and evolution, lunar science, meteoritics and small bodies, asteroid differentiation, planetary mission science and technology, regolith processes on asteroids and the Moon, advanced analytical techniques, fireball observations and orbital dynamics, and links with the exoplanet and stellar evolution astrophysical communities. We are eager to see the collaborative scientific discoveries that result from this partnership,” says Yvonne Pendleton, Director of SSERVI.

The proposal submitted by Principal InvestigatorProfessor Phil Bland (Curtin University in Perth) and Deputy Director Dr Marc Norman (Australian National University in Canberra) included colleagues from a number of institutions across the country and represented a wide breadth of expertise from Australia’s planetary science community. The proposal was selected for Affiliate Membership after it was determined that complementary research activities will help NASA achieve its goals for human exploration of the solar system.

“This is a special moment for Australia,” says  Bland, from the Department of Applied Geology at the Curtin WA School of Mines.

“We are confident that this partnership will result in more great scientific discoveries in planetary science for both our our nations, as well as furthering the SSERVI goal of advancing basic and applied lunar and planetary science research and advancing human exploration of the solar system through scientific discovery.”

Curtin University Vice-Chancellor Professor Deborah Terry says the link with NASA was a fantastic opportunity for Curtin’s staff and students to engage with the global leader for space exploration.

“Given Curtin’s existing expertise in radio astronomy and involvement in the ground-breaking international Square Kilometre Array project, the partnership with NASA is a covetable attachment with many benefits,” says Terry.

“Our Australian partners have put together a compelling proposal that outlines multiple topics for potential collaborative research. We look forward to fruitful scientific collaborations, which will include the study of future potential mission concepts. This partnership will be important to NASA and its international partners successfully conducting the ambitious activities of exploring the solar system with robots and humans, and we look forward to a long and close partnership between our respective countries,” says Greg Schmidt, Deputy Director of SSERVI, who also directs international partnerships for the Institute.

“We look forward to fruitful scientific collaborations, which will include the study of future potential mission concepts. This partnership will be important to NASA and its international partners successfully conducting the ambitious activities of exploring the solar system with robots and humans, and we look forward to a long and close partnership between our respective countries.”

This article was first published by Curtin University on 30 July 2015. Read the article here.

Based and managed at NASA’s Ames Research Center in Moffett Field, California, SSERVI is a virtual institute that, together with international partnerships, brings researchers together in a collaborative virtual setting. The virtual institute model enables cross-team and interdisciplinary research that pushes forward the boundaries of science and exploration. SSERVI is funded by the Science Mission Directorate and Human Exploration and Operations Mission Directorate at NASA Headquarters in Washington.

Find more information about SSERVI and selected member teams here.

New web-based ram selection app wows sheep breeders

The web-based app was launched today by the Cooperative Research Centre for Sheep Industry Innovation (Sheep CRC). The Sheep CRC developed the tool in conjunction with Telstra, Australia’s leading telecommunications provider, and leading software development company Pivotal Labs in San Francisco.

The NSW Department of Primary Industries has also been extensively involved throughout the development of the app, providing expertise from the initial concept to the final product.

During the final test runs before launch, approximately 20 sheep breeders, commercial producers and advisers previewed the system, which they say will dramatically simplify the ranking and purchase of rams, based on Australian Sheep Breeding Values (ASBVs).

Leading farm adviser Craig Wilson, of Craig Wilson & Associates, NSW, says RamSelect.com.au will take the hard work out of using ASBVs when searching for the right genetics to improve flock productivity. “RamSelect.com.au will be a game changer,” Wilson says. “We have known for a long time that ASBVs allow us to compare animals on genetic merit, without the effect of feeding or environment. The RamSelect app makes it quick and easy to rank animals against individual breeding objectives.

“For a lot of commercial producers, sifting through long lists of objective data was time consuming and difficult work – they can now find the genetics they need in a matter of seconds, and know that the recommendations are supported by objective data from Sheep Genetics.”

Sheep CRC chief executive James Rowe said RamSelect.com.au would also be an important marketing tool for breeders assisting clients to select ram teams.

“More and more commercial breeders are demanding objective ASBV data when shopping for rams,” says Rowe. “RamSelect.com.au ensures ram buyers can quickly check rams on offer against their breeding objective and prepare a ranked list prior to sale day. On sale day the buyer only needs to check the visual traits before making their purchase decisions.”

RamSelect.com.au is accessible on a computer, tablet or phone. It will search the Sheep Genetics databases – MERINOSELECT, LAMBPLAN and DOHNE MERINO – to quickly identify and rank rams for a defined breeding objective.

This article was first published on 23 July 2015 by the Sheep CRC. Read the original article here.

Buy Vision, Give Sight

Eyewear brand Revo and U2 lead singer Bono are joining forces with the Brien Holden Vision Institute to eliminate avoidable blindness and vision impairment.

“Eye tests and eye examinations are at the front line of eye care. But for millions of people without access, the simplest problems go untreated. It’s unnecessary and avoidable,” says Kovin Naidoo, Global Director of Programs, Brien Holden Vision Institute.

When consumers purchases Revo sunglasses, $10 from the sale of every pair will be donated by Revo to the “Buy Vision, Give Sight” initiative. To execute the initiative, Revo and Bono are partnering with the Brien Holden Vision Institute to provide sustainable solutions for eye care and end avoidable blindness and vision impairment in under-resourced communities.

Bono, who has a long track record in global health, particularly as an activist in the fight against HIV/AIDS, was diagnosed with glaucoma 20 years ago. His experience with glaucoma, for which he has received excellent treatment, has made him determined to find a way to increase access to frontline eye health services for others.

bono_vision

“The ‘Buy Vision, Give Sight’ campaign is a very personal one for me,” says Bono.

“Thanks to good medical care my eyes are okay, but tens of millions of people around the world with sight problems don’t have access to glasses, or even a basic eye test. Poor eyesight may not be life-threatening, but it dramatically affects your life and your livelihood if you aren’t able to fix it.  When we met with experts, they said the number one problem is untreated poor vision, which prevents a child from learning in school, or an adult from performing their job. Sight is a human right and the ‘Buy Vision, Give Sight’ initiative will help ensure millions of people have access to the eye exams and glasses they need to see.”

Untitled-1

 

“With Brien Holden, we found a partner doing remarkable work, hand-in-hand with local communities.  It’s mind-expanding what they are achieving; we’re very excited to work in partnership with them and Revo,” says Bono.

Yehuda Shmidman, Sequential Brands Group CEO, commented, “We are very excited about this partnership. Revo’s pioneering lens technology has always put eye-health central to Revo products and we believe Revo buyers will embrace the idea that their purchase is helping someone else. We’re very proud to support Bono and the Brien Holden Vision Institute in their efforts to bring basic eye care services to millions of people around the world.”

Professor Brien Holden, CEO, Brien Holden Vision Institute says,”It is extremely helpful that Revo and Bono recognise the impact that uncorrected vision impairment has on the lives of the 625 million people globally who do not have access to a simple eye examination or pair of glasses.  Revo and Bono’s commitment to our programs will have a lasting impact on millions of lives globally.”

The funds donated by Revo will help pay for basic eye care services, particularly eye tests and prescription glasses, and also build stronger eye care services in target communities for the longer term by training local people to provide eye care and detect eye diseases.

During U2’s Innocence + Experience World Tour, Bono will exclusively wear Revo sunglasses. He has designed a capsule collection of sunglasses for the brand, available in the North American fall, which will include lenses outfitted with Revo’s LMSTM technology. As with all Revo sunglasses, $10 dollars from each pair of the Bono for Revo collection will go to the Brien Holden Vision Institute.

This article was published by the Brien Holden Vision Institute on 25 July 2015. Read the original article here.

Robot automates bacteria screening in wine samples

A robotic liquid handling system at the Australian Wine Research Institute (AWRI) is automating the screening of large numbers of malolactic bacteria strains.

Using miniaturised wine fermentations in 96-well microplates, the Tecan EVO 150 robotic system is screening bacteria for MLF efficiency and response to wine stress factors such as alcohol and low pH.

The bacteria are sourced from the AWRI’s wine microorganism culture collection in South Australia and elsewhere.

The robot can prepare and inoculate multiple combinations of bacteria strains and stress factors in red or white test wine, and then analyse malic acid in thousands of samples over the course of the fermentation.

In one batch, for example, 40 bacteria strains can be screened for MLF efficiency and response to alcohol and pH stress in red wine, with over 6000 individual L-malic acid analyses performed.

The AWRI says that this high-throughput approach provides a quantum leap in screening capabilities compared to conventional MLF testing methods and can be applied to a range of other research applications.

Additionally, the phenotypic data obtained from this research is being further analysed with genomic information, which will identify potential genetic markers for the stress tolerances of malolactic strains.

First published at foodprocessing.com.au on 22 July. Read the original article here.

This article was also published by The Lead on 22 July 2015. Read the article here.

Two microbes hold key to superior feed crops

Scientists have identified two microbes that build bigger and more resilient feed crops, potentially boosting farmers’ bottom lines by millions of dollars.

The biotechnology research conducted at Flinders University in South Australia identified two strains of microbes that dramatically increase the ability of lucerne to fix atmospheric nitrogen, boosting the feed crop’s early growth and resilience, and ultimately its yield.

Research by medical biotechnology PhD student Hoang Xuyen Le drew on the hundreds of strains of endophytic actinobacteria, which grow naturally within legume roots. His research isolated and identified two strains of microbes that in laboratory and glasshouse trials were shown to promote growth in the shoots of the legume plants.

The research was supervised by Professor Chris Franco from Flinders and Ross Ballard from South Australian Research and Development Institute (SARDI). A patent has been lodged in relation to the two strains.

Nitrogen is absorbed by the plants through the formation of external nodules by symbiotic rhizobium bacteria that grow in the nodules. Franco says that following the inoculation of the lucerne seeds with spores of the actinobacteria, the nodules grew significantly larger, fixing greater amounts of nitrogen.

“Up to 50 or even 70 per cent more nitrogen was fixed,” says Franco.

The effect was to substantially improve the establishment of the lucerne, increase its resilience in drought conditions and also boost its yield.

“We found that our two main strains gave us a crop yield increase of 40 to 50 per cent in the glasshouse, and we would look for at least a 20 per cent improvement in the field,” says Franco.

He says as much as 25 per cent of the higher levels of nitrogen persisted in the soil, improving the growing conditions for subsequent crops.

The Flinders biotechnologists will now expand their trials on lucerne in the field, and will also look for similar effects in other legume crops, including peas, chick peas and faba and soya beans.

Further research is required to understand the underlying mechanism of the bugs: while it is likely that their natural propensity to produce bioactive compounds is partly responsible for increasing the general robustness of the inoculated lucerne by reducing disease, they may also be encouraging the growth of rhizobium bacteria in the soil.

Franco says that actinobacteria offer an environmentally friendly way of controlling disease, especially fungal root diseases such as Rhizoctonia, reducing the need for fossil-derived pesticides and fertiliser.

The potential to capture atmospheric nitrogen offers a major environmental benefit.

The legume seed crop, based in the South East of South Australia, is the basis of a national feed industry worth close to $100 million a year.

“This is very good news all round,” says Franco.

This article was first published by The Lead on 22 July 2015. Read the original article here.

Driverless car trials in South Australia

A major European carmaker will conduct the first on-road trials of driverless cars in the Southern Hemisphere in South Australia in November.

The testing by Volvo will be held in conjunction with an international conference on driverless cars in Adelaide.

Volvo will test the same vehicle being used in their “Drive Me” project in Sweden.

South Australia legalized the use of driverless cars on its roads earlier this year.

The testing is part of independent road research agency ARRB’s Australian Driverless Vehicle Initiative.

ARRB Managing Director Gerard Walton said that automated vehicles are a short-term reality that Australia needs to be prepared for.

“The South Australian Government has been quick to recognise this,” he said.

“ARRB will establish how driverless technology needs to be manufactured and introduced for uniquely Australian driving behaviour, our climate and road conditions, including what this means for Australia’s national road infrastructure, markings, surfaces and roadside signage,” said Waldon.

Volvo’s testing will be undertaken in conjunction with Flinders University, Carnegie Mellon University, the RAA and Cohda Wireless.

The Premier of South Australia, Jay Weatherill said the technology promises to not only improve safety, reduce congestion and lower emissions, but also to provide a real opportunity for South Australia to become a key player in the emerging driverless vehicle industry.

“This trial presents a fantastic opportunity for South Australia to take a lead nationally and internationally in the development of this new technology and open up new opportunities for our economy,” he said.

The driverless car trials will take place on an expressway south of the capital city of Adelaide on 7–8 November 2015.

Multiple vehicles will conduct manoeuvres such as overtaking, lane changing, emergency braking and the use of on and off ramps.

The International Driverless Cars Conference will be hosted at the Adelaide Convention Centre and Tonsley precinct on 5–6 November 2015.

This article was first published by The Lead on 21 July 2015. Read the original article here.

The big business of hearables

It’s Friday night and the restaurant is packed. You’re out with friends and you realise that you can’t follow the conversation. You have to keep asking people to repeat themselves. You could get your ears checked… but you’re not old – how could you already have hearing loss?

Many people may unknowingly expose themselves to high-risk situations that affect their hearing health. Young Australians are particularly at risk through exposure to music players, live music venues and nightclubs where noise can reach dangerous levels.

“Hearing disability is truly the invisible handicap, we don’t see the problem, but it has real impact on the everyday functioning of those who suffer it,” says Professor Robert Cowan, CEO of the HEARing CRC, Australia’s hub for hearing healthcare research.

Part of the problem is the view that hearing loss is only an issue in old age. But the truth is that one in six Australians suffers from some form of hearing loss.

“When people have trouble reading fine print, they will generally straight away visit an optometrist or pick up a pair of magnifier glasses from a chemist, because it’s a socially acceptable disability and there is no associated stigma with wearing glasses,” says Cowan.

“But when someone has a hearing disability, they often choose to ignore it, or to blame others for mumbling or speaking too softly, and as a result they postpone assessment and treatment,” says Cowan.

Turn it up

“Hearing patients and professionals would both benefit from new hearing technology that provided a seamless fit into everyday life,” he says.

There’s plenty of new tech entering the market from consumer electronics powerhouses. According to Business Korea, Samsung is intending to develop a product for 2016, while Apple has already joined forces with hearing aid developers GM ReSound.

Hearables, as they have been dubbed, are smart ear devices that feature 3D audio notification. By providing users with real time data, they help to build awareness of exposure to high levels of noise or to noisy environment for prolonged periods of time.

“Noise-induced hearing loss is akin to sunburn, it’s a combination of the loudness (i.e. like the UV rating), the duration of any exposure, and the frequency of exposure,” says Cowan.

Take ReSound’s iPhone-connected LiNX headphones. They connect to Apple products and allow the wearer to hone in on or deflect sounds with the touch of a screen, to dial down the noise around you, or direct the speech focus towards your dinner partners and away from the other table’s conversations, for example.

Tech such as this is increasingly big business. Wearable tech company Doppler Labs announced this month that they have raised US$17 million for its Here Active Listening System, that uses two wireless buds and a smartphone app to control what you hear and how you hear it. They also raised US$635,000 directly via crowd funding.

In Australia, Perth-based hearable Nuheara is the first wearables company to list on the ASX. Their tech, which was launched in June 2014, is a hybrid between assisted listening devices, Bluetooth earplugs and noise-cancelling headsets without cables or wires.

Cowan hopes that this technology will change the way people associate hearing aid technology with old age, and spur them to seek help much earlier.

We use our phones every day, and new apps that can help us hear or assess our risk of hearing loss can be at our fingertips, changing the way that we provide hearing healthcare,” he says.

“Hearables will increase our connectivity, and allow for individuals to personalise hearing care like never before.”

Kara J Norton

 

 – HEARing CRC

 

Closing the gap

Romlie Mokak, CEO of the Lowitja Institute for Aboriginal and Torres Strait Islander Health Research, is a man with a vision.

“We’ve got a clear agenda for the future and it’s for just 15 years ahead: 2030. This agenda has been agreed upon by governments and Aboriginal and Torres Strait Islander leadership as part of the ‘Close the Gap’ campaign,” said Mokak.

The aim is to eliminate the difference in life expectancy between Aboriginal and Torres Strait Islander people and other Australians by 2030. It’s a big ambition that will take a lot of work.

“It’s essential that solutions in Aboriginal and Torres Strait Islander health and wellbeing come from the people themselves,” he said. A vital step is explicit recognition of Indigenous people in the Australian Constitution, supported by the Recognise Health coalition launched by the Lowitja Institute in March 2015.

“If we hit the target, then by 2040 we will have had 10 years with no gap. We will have a high quality, accessible health system that is culturally appropriate for Aboriginal and Torres Strait Islander people.”

Since 1997, the Lowitja Institute and its predecessor CRCs have led a substantial reform agenda in Aboriginal and Torres Strait Islander health research by working with communities, researchers and policymakers. In partnership with 21 participants, the CRC is poised to make a substantial contribution to the goals for 2030 and towards a 2040 that sees Aboriginal and Torres Strait Islander participation and leadership in all walks of Australian life.

— Clare Pain

lowitja.org.au

Feature image: Smoking ceremony conducted by Wurunjeri Elder Aunty Joy Wandin Murphy at the Lowitja Institute CRC launch in October 2014.

 

Shark detection

Sharks have an incredible sense of smell, but it is their sense of hearing that could be one of the keys to protecting people at beaches, says a team of researchers led by Dr Christine Erbe from Curtin University’s Centre for Marine Science and Technology.

“We had this idea of trying to figure out what acoustic signatures humans make, whether the sharks can hear them, and, if appropriate, whether we can somehow interrupt that,” says Erbe. These interruptions could then potentially be used to ‘hide’ or ‘mask’ the noises people make in the water from the sharks.

Western Australia is a pertinent place to work on this project, given the debate over baited drum lines to cull sharks, and the project has been funded by Western Australia’s Department of Commerce.

Initial recordings have been made of people in a pool swimming and snorkelling past a hydrophone – a microphone designed to record or listen to underwater sound. Erbe’s team records people swimming and surfing at beaches to see how far their noises travel. These sounds can then be played to sharks in enclosures at Ocean Park Aquarium in Shark Bay to check for any responses.

“If we see responses from the sharks, the next step is to figure out if we can mask the sounds of people in the water using artificial signals,” says Erbe. These artificial signals are band-limited white noise, created digitally. “We can see which frequencies, or part of the human sound signature, could be detected by the sharks and calculate the range limits at which that might occur. We can then design masking signals that fill in around them so those frequencies can’t be detected,” she says. The team will test these masking signals by playing them back to the sharks at Ocean Park Aquarium.

The outline of a shark shows clearly on a scanner used by the Curtin team.

The outline of a shark shows clearly on a scanner used by the Curtin team.

This masking technique is different to other approaches where loud sounds are played at beaches to scare sharks away. The problem with the loud sound approach, says Erbe, is that it potentially interferes with an entire underwater ecosystem. The masking approach, on the other hand, is targeted at frequencies and levels that only sharks can hear in the surf zone. “We’re not looking at scaring the sharks away, we’re just limiting them from detecting humans,” she says.

According to Erbe, a multidisciplinary approach is crucial to solving problems such as shark mitigation, and her team ranges from physicists to acousticians, engineers and marine biologists.

Team member Dr Miles Parsons is leading another project on the sonar detection of sharks with the aim of building an early warning system. “The solution will have to be a combination of detecting sharks and preventing them detecting us,” says Erbe.

Ruth Beran

cmst.curtin.edu.au

Multi-million-dollar deal brings UQ pain drug closer to reality

A chronic pain treatment discovered at The University of Queensland is a step closer to clinical use, with a global pharmaceutical giant acquiring the Australian-founded company developing the drug.

Spinifex Pharmaceuticals has been acquired by Novartis International AG for an upfront cash payment of $US200 million (about $A260 million), plus undisclosed clinical development and regulatory milestone payments.

Spinifex is a biopharmaceutical company founded by UQ commercialisation arm UniQuest.

UQ Vice-Chancellor and President Professor Peter Høj welcomed the acquisition and congratulated those involved.

“This is one of the largest Australian biotech deals in history, and is a stunning outcome for the company, the researchers and the investors,” Professor Høj said.

“Spinifex builds on the unprecedented commercial translation achievements of UQ, which includes the world’s first cancer vaccine, Gardasil.

“It is a shining example of UQ’s determination to take research from excellence to what I call ‘excellence plus’, developing a product that has potential to improve the lives of people around the world.”

Spinifex is developing the drug candidate EMA401, an oral treatment for chronic pain, particularly neuropathic pain (a type of nerve pain), without central nervous system side effects.

The technology is based on a discovery by UQ’s Professor Maree Smith.

Professor Smith said the acquisition brought EMA401 a step closer to the people who needed it most.

“Chronic pain can be a debilitating condition, most commonly associated with cancer chemotherapy, post-herpetic neuralgia (a painful condition that can follow shingles), diabetes, peripheral nerve injury and osteoarthritis.

“It’s wonderful to see this deal eventuate, bringing a much-needed treatment option a little closer to reality for the millions of pain sufferers around the world,” Professor Smith said.

UQ pain researcher Professor Maree Smith

UQ pain researcher Professor Maree Smith

UniQuest CEO Dr Dean Moss said Dr Smith’s work was at the cutting edge of pain research.

“Her achievements and expertise have contributed to the formation of the recently-launched Queensland Emory Drug Discovery Initiative (QEDDI),” Dr Moss said.

QEDDI, a collaboration between UQ and Emory University in the US, will see the development of drugs to combat health issues including cancer, diabetes, inflammatory disorders and infectious diseases.

EMA401 is a novel angiotensin II type 2 (AT2) receptor antagonist being developed as a potential first-in-class oral treatment.

Professor Smith and UQ’s Dr Bruce Wyse’s research identified AT2 receptor antagonists as inhibitors of neuropathic and inflammatory pain in preclinical models.

Spinifex is supported by a syndicate of investors, including UniQuest, NovoVentures (Novo A/S), Canaan Partners, GBS Venture Partners, Brandon Capital Partners and UniSeed (a venture fund operating at the Universities of Melbourne, Queensland and New South Wales).

Dragonfly eyes inspire machine vision

Mechanical Engineering PhD Student Zahra Bagheri at the University of Adelaide in South Australia says that despite having low visual acuity and brains no bigger than a grain of rice, dragonflies are remarkably good at tracking prey.

“They’re not like mammals which have developed very good brains, and they have very low resolution eyes compared to other animals, but they can catch their prey more than 97 per cent of the time while they’re moving at very high speeds in very cluttered environments,” Bagheri says.

“That means they have adopted very efficient methods for target tracking.”

Bagheri is part of a team of engineers and neuroscientists that have used those methods to develop a machine vision algorithm that can be applied in a virtual reality simulation, allowing an artificial intelligence system to ‘pursue’ an object.

Her project is a combination of neuroscience, mechanical engineering and computer science, building on years of research in to insect vision already undertaken at the University of Adelaide.

Zahra Bagheri and Benjamin Cazzolato with the robot that will use the newly developed machine vision algorithm.

Zahra Bagheri and Benjamin Cazzolato with the robot that will use the newly developed machine vision algorithm.

“Detecting and tracking small objects against complex backgrounds is a highly challenging task. Consider a cricket or baseball player trying to take a match-winning catch in the outfield,” Bagheri explains.

“They have seconds or less to spot the ball, track it and predict its path as it comes down against the brightly coloured backdrop of excited fans in the crowd – all while running or even diving towards the point where they predict it will fall!”

This is known as selective attention. Dr Steve Wiederman is leading the dragonfly project, and conducted the original research recording the responses of neurons in the dragonfly brain.

“Selective attention is fundamental to humans’ ability to select and respond to one sensory stimulus in the presence of distractions,” Dr Wiederman says.

“Precisely how this works in biological brains remains poorly understood, and this has been a hot topic in neuroscience in recent years,” he says.

“The dragonfly hunts for other insects, and these might be part of a swarm – they’re all tiny moving objects. Once the dragonfly has selected a target, its neuron activity filters out all other potential prey.”

“It has diverse applications. It can be used in surveillance, wildlife monitoring, smart cars and even bionic vision.”

The team has emulated that ability with their algorithm. Rather than trying to perfectly centre the target in its field of view, Bagheri says the system locks on to the background and lets the target move against it.

“This reduces distractions from the background and gives time for underlying brain-like motion processing to work. It then makes small movements of its gaze and rotates towards the target to keep the target roughly frontal,” Bagheri says.

Because the algorithm is based on a dragonfly’s small brain and limited vision, it can rival insects’ abilities as well as those of more elaborate machine vision systems – all with relatively low complexity.

“It’s shown that we can do it with very low resolution cameras and very limited computational resources. It doesn’t need high-performance computers or anything like that.”

This bio-inspired “active vision” system has been tested in virtual reality worlds composed of various natural scenes. The Adelaide team has found that it performs just as robustly as the state-of-the-art engineering target tracking algorithms, while running up to 20 times faster.

“We are hoping to test it on a robot – we’re working on that right now. It has diverse applications. It can be used in surveillance, wildlife monitoring, smart cars and even bionic vision.”

Bagheri is lead author of the paper, titled Properties of Neuronal Facilitation that Improve Target Tracking in Natural Pursuit Simulations, which was published this week in the Journal of The Royal Society Interface.

This article was published on The Lead on the 11th June 2015. Read the original article.

Australia’s energy future

Australia’s renewable resources include wind, solar, wave and geothermal energy, and there’s significant research happening to improve generation and storage technologies to overcome the inherent disadvantage of intermittent flow.

The Australian Renewable Energy Agency (ARENA) has completed 32 projects and is managing more than 200 others, including several large-scale solar photovoltaic (PV) plants and wind farms, which are considered the most advanced technologies in terms of making a short-term impact on our renewable electricity generation.

Australia’s CRC for Renewable Energy (ACRE), which operated 1996–2004, developed a state-of-the-art facility for testing grid-connected renewable energy systems, as well as small-capacity wind turbines for remote generation.

Australian scientists at the CRC for Polymers (CRC-P) have made big strides in the development of flexible, lightweight solar cells, which CEO Dr Ian Dagley describes as the “antithesis” of rigid rooftop solar cells. These lightweight cells offer intriguing possibilities: their flexibility means they can be placed on a variety of surfaces, from walls to windows, and they can operate indoors to help charge electrical devices.

They’re also attractive because they’re considerably cheaper to manufacture than silicon solar cells. Dagley says his CRC-P team has been working on refining the manufacturing technique, which uses low-cost components and reel-to-reel printers. One of the goals is to increase the lifespan of the cells, which is about five years, whereas rigid cells last roughly 30 years.

Meanwhile, the CRC for Low Carbon Living (CRCLCL) is looking at ways to dramatically reduce greenhouse gas emissions by developing smarter, more energy efficient buildings and cities. CEO Dr Deo Prasad says lower carbon buildings can be realised by optimising design to ensure maximum energy efficiency, through integration of next-generation technologies, such as solar PV cladding and heat and electricity capture systems for on-site energy offsets, and by using more sustainable building materials that need less energy to extract, process and manufacture. At the suburb and city scale, Prasad says decentralised renewable energy generation, reliable storage and smart grids, linked with information and communications technology-based intelligence, will lower carbon impacts.

“We recognise there is not going to be a silver bullet solution to carbon reductions,” says Prasad. “The approach needs to be holistic and driven by industry and governments.”

There are challenges associated with increased renewable energy levels, but Australia’s National Electricity Market seems to be handling integration well so far, says Dr Iain MacGill, joint director of the UNSW Centre for Energy and Environmental Markets. Studies by the Australian Energy Market Operator show it’s possible to operate the national grid with 100% renewables. “It won’t be cheap – just a lot cheaper than unchecked climate change,” MacGill says.

Russell Marsh, director of policy for the Clean Energy Council, emphasises the importance of commitment. “Investors need long-term certainty to ensure a rate of return,” says Marsh. “The Federal Government needs to lock in a firm, long-term target.”

MacGill agrees that the right policies can incentivise investment, but adds that it requires leadership and social consensus. “Australia is contradictory on clean energy. We have an early history and remarkable success in renewable energy deployment, and fantastic renewable resources. But we are also among the world’s largest coal and gas exporters,” he says.

“Will we take a leadership role, or do all we can to keep our international coal and gas customers buying from us?”

energy5


Remodelling energy

While coal and gas continue to be our dominant energy sources, the once-burgeoning renewables industry has been hindered by the Federal Government’s recent review of the Renewable Energy Target (RET). The review recommended scrapping the 20% target for renewable electricity generation by 2020, resulting in political deadlock and investor uncertainty across the renewable energy sector.

Bloomberg New Energy Finance’s Australian head, Kobad Bhavnagri, says the review was especially damaging because it came “very close to making retroactive changes to a policy”.

“Whenever retroactive changes are made to policy it becomes, essentially, Ebola for investors,” he says. “When governments act unpredictably and destroy the value of existing assets, it scares people – for a long time.”

Australia generates more carbon emissions per person than any other OECD country. One-third are generated by the electricity sector, in which coal and natural gas account for roughly 85% of generating capacity. Renewables, mostly from hydropower, account for about 15%.

Reaching the 20% target during the next five years will not be cheap. At the time of the review it was estimated that another $18 billion of investment would be required to reach the target.

But the costs associated with increased generating capacity are yet to be weighed against the costs of potentially catastrophic climate change. Scientists have warned a 2°C increase in overall average temperatures from pre-industrial levels is the limit our planet can withstand before the effects of climate change become irreversible.

In December 2014, following the release by the International Energy Agency (IEA) of its report World Energy Outlook 2015, the agency’s chief economist and director of global energy economics, Dr Fatih Birol, told Bloomberg’s Business Week that global investment in renewable energy needs to quadruple to a yearly average of $1.6 trillion until at least 2040, to stay below that warming threshold.

Some of the world’s biggest economies have taken note. Estimates by the Climate Interactive indicate the US-China emissions deal, if implemented in full, could keep some 580 billion tonnes of CO2 out of the atmosphere between now and 2030 – more than all global fossil fuel emissions from 1990 to 2013.

In 2014 – while China spent US$64 billion on large-scale clean energy projects, increasing its 2013 total by about US$10 billion – the USA spent nearly US$13 billion on utility-scale renewables and continued to expand production of its almost carbon-neutral shale gas reserves (see here for Australia’s progress).

Research by Bloomberg New Energy Finance found Australian investment in large-scale renewable energy in 2014 was US$223 million – the lowest in more than a decade. 2014 saw Australia nose-dive from 11th largest investor in commercial clean energy projects to 39th, behind developing nations such as Honduras and Myanmar.


The 2040 outlook

If Australia is serious about boosting its capacity for renewable energy, 2040 is a good deadline, says Iain MacGill, joint director (engineering) for the Centre for Energy and Environmental Markets at UNSW Australia – by then we’ll need “a major infrastructure transition”.

Russell Marsh is Director of Policy for the Clean Energy Council, the peak body representing Australia’s clean energy sector. “With the right level of support we could see the deployment of renewable energy at least double between 2020–2040,” he says. “But if the target is not extended beyond 2020, it is unlikely that we will see further growth.”

This view is backed by the Australian government’s Bureau of Resources and Energy Economics (BREE). In a November 2014 report looking towards mid-century electricity production, it reported “In the absence of potential new policy initiatives, the relative shares of fossil fuels and renewables in electricity generation are not likely to change significantly”.

In fact, BREE’s projections show renewable generating capacity remaining stable, meeting 20% of Australia’s total demand from 2020–2050. In this scenario, coal-fired power would still account for 65% of electricity by mid-century.

There are concerns that the current policy uncertainty is reaching a tipping point, which could see companies exiting Australia or going into distress.

Policy uncertainty  is taking a toll on  the business end of renewable energy.

Policy uncertainty is taking a toll on the business end of renewable energy.

In July 2014, RenewEconomy reported that Recurrent Energy, a US solar power plant developer being acquired by Canadian Solar, was planning to cease its Australian operations, citing concerns over policy uncertainty. Several other large international renewable energy companies, including Spain’s Acciona and US-based First Solar, have warned of possible exits, should the Renewable Energy Target be amended.

MacGill says exits are inevitable. “Why would an internationally focused renewable energy company stay if there is no prospect for their projects to go forward?

“They can, should and will depart at some point,” he says. “And with their departure, we will lose institutional capacity – such as people, money and industrial knowhow – which will inevitably
slow our ability to deploy clean energy, and increase its costs.”

Marsh agrees the risk to the industry is significant. “Every day, week and month that goes by with a cloud hanging over support for the renewable energy industry are days, weeks and months when our international competitors are racing ahead of us – and reaping billions of dollars in investment in this global growth market.”

Dr Deo Prasad, CEO of the CRC for Low Carbon Living, says that while the effects aren’t as dramatic, policy uncertainty also impacts the research community, especially “end-user driven projects where collaboration is essential”.

“Many a research direction and focus has had to change over the years, for the worse, due to policy uncertainty,” he adds.

Myles Gough

CRC for Low Carbon Living

CRC for Polymers (CRC-P)

Exploring carbon capture and storage futures

The Great Ocean Road, about 200 km southwest of Melbourne, draws millions of tourists to view the spectacular cliffs and limestone stacks known as the Twelve Apostles, carved by relentless Bass Strait waves and winds. But this region is as rich in fossil fuels as it is in scenic beauty, and several commercial gas fields have been opened in the Otway Basin along the continent’s southern margin.

There is also the CRC for Greenhouse Gas Technologies’ (CO2CRC) flagship carbon capture and storage (CCS) trial: the CO2CRC Otway Project – the world’s largest demonstration of its kind.

Since the project started in 2008, the Australian government, US Department of Energy and CRC partners have funded the injection of more than 65,000 tonnes of CO2 into the Otway Basin’s depleted gas fields, without leakage or measurable effect on soil, groundwater or atmosphere.

The project was further boosted by $25 million in Australian government funding in February this year. “The wide-scale deployment of CCS is critical to reduce carbon emissions as quickly and cost-effectively as possible,” says CO2CRC chief executive Tania Constable. “This funding will enable CO2CRC to embark on a new program of research to improve CCS technologies.”


Australia is well-endowed with natural resources. Its known uranium reserves are the world’s largest, and it is rich in natural gas. Traditionally, the most important resource has been coal: Australia has the fourth largest coal reserves globally and is the world’s second biggest coal exporter behind Indonesia. Coal exports – which have grown 5% annually over the past decade – will earn $36 billion in 2014–2015.

Figures like these have led Prime Minister Tony Abbott to declare coal “an essential part of our economic future”. Professor Chris Greig, Director of the University of Queensland’s Energy Initiative, a cohort of research expertise across all energy platforms, anticipates the country will continue to be reliant on fossil fuels, including coal, until at least mid-century. But just how far beyond that depends on how the world – particularly China, one of Australia’s biggest coal customers – addresses future climate change.

In 2014, the US-China emissions deal set China a goal to source 20% of its energy from zero-emissions sources and peak its CO2 emissions by 2030. In August 2014, amid worsening public sentiment over air pollution, the Beijing Municipal Environmental Protection Bureau announced that it would be phasing out coal-fired power in the capital’s six main districts by 2020.

China has been pouring money into the development of renewable energy technologies, spending an estimated US$64 billion on large-scale clean energy projects in 2014 alone. This was five times more than the next biggest spender, according to market analyst Bloomberg New Energy Finance. China is also investing heavily in CCS technologies, with at least 12 projects currently underway.

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There are several pathways toward reducing emissions from the electricity sector – from the adoption of nuclear energy and greater uptake of renewable sources and natural gas, to more efficient power plants and modified diesel engines that can burn liquefied coal. CCS, however, is one of the most promising methods for reducing emissions from coal-fired power stations. Capture technologies isolate and pump CO2 underground to be stored in the pores of rocks (see graphic page 29).

Rajendra Pachauri, who until early 2015 was Chair of the Intergovernmental Panel on Climate Change, told the UN 2014 Climate Summit in New York, in September 2014: “With CCS it is entirely possible for fossil fuels to continue to be used on a large scale”.

Dianne Wiley, CO2CRC’s program manager for CCS, says CO2 capture technologies are already available to install. Their deployment is limited by high costs, but there have been strong successes. Wiley points to the commercial scale Boundary Dam Integrated Carbon Capture and Sequestration Demonstration Project in Saskatchewan, Canada – the world’s first large-scale power plant to capture and store its carbon emissions – as a good example of what’s possible with CCS technology. It became operational in October 2014 and, its operators say, is already “exceeding performance expectations”. The CAN$1.3 billion cost of the system should drop by around 30% in subsequent commercial plants, says Brad Page, CEO of the Global CCS Institute.


Greig says that investment decisions in favour of CCS in Australia won’t happen until more work is done to find high-capacity storage basins around the continent that can safely and reliably store CO2 emissions for several decades.

Constable says the recent injection of capital from the Federal Government to the Otway Project will help the CRC take the necessary steps to meet this challenge. She says it will “lower the costs of developing and monitoring CO2 storage sites, enhance regulatory capability and build community confidence in geological storage of CO2 as a safe, permanent option for cutting emissions from fossil fuels”.

Retrofitting CCS technology to existing plants isn’t an option: Greig likens that to “building a brand new garage onto the side of a house that’s falling down – you just don’t do it”. CCS would therefore require investment in new coal-fired power stations.

“A well-conceived energy policy for the electricity generation sector would see ageing, low-efficient plants replaced with high-efficiency ultra-supercritical [coal] plants,” says Greig, adding that these plants have lower emissions simply by virtue of their efficiency and could achieve emissions reductions of 25% compared to existing plants.


How CCS works

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The first step of carbon capture and storage (CCS) is capture. It involves separating CO2 from other gases in the exhaust stream from a fossil fuel power plant or some other industrial facility. This can be done with solvents that absorb CO2 or with ceramic and polymer membranes that act as filters. Once isolated, CO2 is compressed into a state in which the difference between liquid and gas can no longer be distinguished. It is then transported via pipeline to a prospective storage site. Here, the CO2 is injected into an underground reservoir, such as a geologic formation or depleted oil field. The CO2 has to enter the rocks without fracturing them, and can then be stored underground for thousands of years.

Myles Gough

CO2CRC