All posts by Heather Catchpole

Science Australia’s business heart

The outcome is loud and clear, the government wants to use CRCs to put science at the heart of Australian business.

CRCs will remain a feature of the Australian innovation landscape. The government only wants to support CRCs that are highly industry focused and only for a single term of up to 10 years. The application process is going to simplified to make it easier and more attractive for business to bid for a CRC.

In a bold and exciting move, they’ll be a new stream in the CRC Program called CRC-Projects (CRC-P). These will again address highly focussed industry issues but at a smaller, more nimble level than a full CRC (which are generally 7 year enterprises of maybe $100 million of activity). CRC-Ps will be up to three years, up to $3.0 million of government support and will be open for application three times a year. This is a huge development to open the CRC Program up more readily to smaller businesses and more specific projects.

Reviewer David Miles recommendations are aimed to discourage CRCs going on for very long terms. While this is a big concern for those addressing long-term innovation issues, the intent is to make the CRC concentrate on solving the problem at hand and exiting, leaving the industry players better off. This is a particularly interesting approach from Mr Miles because, prior to the commencement of his review, there was one train of thought that success in a CRC meant an ongoing body. The previous Parliamentary Secretary, Bob Baldwin, had publicly asked why more CRCs don’t continue as self-sufficient organisations beyond their government funding period?

Miles downplays the importance of an ongoing organisation in his review, making it clear that the real benefits from a CRC come when the industry players involved implement the research.

Miles also sees the industry training role of CRCs as very effective and important, encouraging more of them to do more in training postgraduates for industry roles.

CRCs that are not specifically aimed at solving industry issues are the potential losers in this Review. Time and again, the review says industry should be “front and centre” of the CRC program, arguing that when the Program tries to do everything, it achieves less. But Miles holds out a possible future for “non-industry” CRCs, encouraging other Government departments to directly fund CRCs through the Department of Industry and Science, Miles points out that this happens already (the Department of Defence funds the Defence Materials Technology Centre through the CRC Program). He points out that the CRC model works and is effective, but the Industry Department shouldn’t have to front for the cost of CRCs outside its portfolio area.

So while it is disappointing that some important areas of research may not qualify for CRCs anymore, the government is leaving the door open for other government departments to participate in the CRC Program.

For Australian business, the CRC Program should become more flexible and simpler for them to get involved in.

Dr. Tony Peacock

Chief Executive

Cooperative Research Centres Association

 

Medicine by design

IT’S 2040. Jane taps her foot nervously, waiting for her smart watch to link to her oncologist via video. Her cancer-screening blood test (routine at age 45) has found circulating tumour cells. Jane is about to find out what type of cancer she has and what her next steps will be.

Her watch beeps, but it’s not the oncologist. Her health app bursts onto the screen telling her she’s been sitting for too long. Time to get up and move for five minutes… Does she want to listen to dance music? Jane’s not in the mood, but she gets up and paces the room.

Miranda, the oncologist, has most of her patient consultations via online telehealth video conferencing. Her first step following Jane’s blood screen result was to download her patient’s genome. Then she ran a computer program to compare Jane’s genome with the set of blood test results that showed she has breast cancer; revealing its type and the cancer cells’ DNA sequence.

Using data from hundreds of thousands of breast cancer cases worldwide, the program helps Miranda devise an optimised treatment program for Jane. She presses the button to begin the consultation.

Miranda breaks the news gently. Cancer is a worry, of course, she says. But things are so much better than they were 25 years ago. She is confident the imaging will find a tiny primary tumour, which can be removed – in a surgical procedure known as a lumpectomy – and then Jane will have drug therapy for several years, with few side effects, to dramatically reduce the chance of the cancer spreading (metastasising).

Most people beat breast cancer nowadays and there is usually no need for chemotherapy, Miranda reassures her.

“One in two of us will get cancer and one in five of us will die from cancer. One of the challenges at the moment is what’s called ‘treating the undetectable’.”

Science fiction? Yes. But it certainly may become science fact, according to Dr Warwick Tong, CEO of the Cancer Therapeutics CRC (CTx), and Professor Bob Cowan, Chief Executive Officer of the HEARing CRC.


Mopping up cancer

In Tong’s view, blood tests – or ‘liquid biopsies’ – to screen for all types of cancers will become routine. The basic technology already exists, at least for colorectal cancer, he explains.

Tong is spearheading a new approach to cancer drug therapy. While most chemotherapy drugs shrink secondary tumours that result from metastasis, CTx is working on ‘mopping up’ cells that migrate from the original tumour at a very early stage.

“One in two of us will get cancer and one in five of us will die from cancer – and 90% of those deaths are caused by vast metastatic spread,” he says. “One of the challenges at the moment is
what’s called ‘treating the undetectable’. We treat primary cancer pretty well nowadays, but often the disease reoccurs years down the track.”

Drugs used in early stage cancer, alongside treatment of the primary tumour, are called ‘adjuvant’ therapies. But, Tong explains, few pharmaceutical companies are exploring adjuvants because the research is expensive and it’s difficult to prove they work. In fact, most of the few existing adjuvants – such as the drug tamoxifen, which is used for breast cancer – were developed for late cancer and have become adjuvants through chance rather than design.

“The focus of our drug discovery program is ‘adjuvant by design’”, says Tong. And it is work like this at the CTx that may lead to 2040 drugs, similar to those Jane will use.


Treating the individual

Jane’s individual treatment protocol will typify 2040 medicine, explains Cowan. “Up to now, evidence-based medicine has been founded on group analysis. But in 2040, instead of applying group statistics to an individual, we’ll be able to understand their particular risk and make treatments more personal.”

At the heart of this lies our ability to sequence a person’s DNA, which can now be done for just a few hundred dollars.

Cowan predicts that the accumulating digital information on individuals will create a “data storm” and, ironically, as individualised treatment becomes the norm, the data available for group analyses will also massively increase. “So there may be factors we have been unable to identify because of variation in the environment and gene expression, which will become clear when we start to get much larger samples,” he explains.

Drawing on his experience in hearing, Cowan foresees major advances in prosthetics. The hugely successful cochlear implant, developed in conjunction with HEARing CRC, is a prosthetic – the union of an artificial device with the human brain. “Australia leads the world in cochlear implants,” he says.

Sadly, one of the major drivers for prosthetics is war. The ravages of landmines and improvised explosive devices have brought increased funding for the development of better prosthetic limbs. The aim now is to marry the prosthetic more intimately with the individual’s own nervous system: something that requires new approaches for regenerating nerve connections.

Cowan’s vision for prosthetics is exciting: “You’ll simply think ‘pick up
the glass’ and your prosthetic arm will execute all the necessary movements as your own arm did in the past.”

creening computational specialist Rebecca Moss at the Cancer Therapeutics CRC  High Throughput Chemical Screening Lab.

Screening computational specialist Rebecca Moss at the Cancer Therapeutics CRC High Throughput Chemical Screening Lab.


Cost-effective medicine

Forecasts for 2040 predict that the
human population will include twice as many people aged 65 or over, which is concerning to Cowan because it means that a greater proportion of people will have problems with hearing and cognition.

“More and more we are going to see the need for reducing the strain
on the health system,” he says, adding that telehealth will be a very important aspect of this. “We need to deliver systems through our broadband network.” Treating more people at home, under medical supervision, rather than in hospital, is the way ahead, he says.

“We need to change the way that we do diagnosis, and involve the individual in managing their own health,” Cowan says, explaining that the technology is already here and it’s the healthcare delivery system that needs to change. “We have technology now that allows us to have a clinician based in Sydney programming a cochlear implant for a child in Samoa.”

The successful translation of Australian research into practice will be vital. “Australian basic medical research is excellent,” Cowan says. “We punch above our weight internationally. But, unless we take knowledge gained from research and translate it into a clinical application, it doesn’t make an economic return for Australia.

“To do that you need to involve clinicians from day one, which is exactly the approach of the medical CRCs.”

Clare Pain

www.cancercrc.com

www.hearingcrc.org

Growing the north

NEW OPPORTUNITIES abound for Australia’s farm industries to expand food exports into Asian markets following landmark free trade agreements with Japan and Korea in 2014.

The Japan-Australia Economic Partnership Agreement (JAEPA) came into force on 15 January 2015, allowing Australian exporters to benefit from two rounds of tariff cuts in the first half of this year. The Korea-Australia Free Trade Agreement (KAFTA) took effect on 12 December 2014, and eliminates tariffs for 84% of Australia’s exports to Korea.

Minister for Industry and Science, Ian Macfarlane, welcomed the agreements as delivering long-term benefits to the national economy, particularly to research and agriculture.

“This is a huge opportunity as Japan is our second largest trading partner and Korea is our fourth, with combined two-way goods and services trade worth more than $100 billion,” he said.

Beef, dairy, honey, herbs, cordials, juices and soft drinks were just a few examples of homegrown food exports that will benefit from greater access to Asian markets, he said.


OVER 25 YEARS, the CRC Program has helped target and secure access to Asia for some of Australia’s biggest food export industries. Australian scientists working in areas such as plant and livestock genetics, food processing, soil nutrients, biosecurity, and improved supply chain management have been vital to establishing links with Asian universities and business leaders.

The Australian Seafood CRC developed new markets for dried, salted and brined products such as mussels, scallops and squid in Japan and Hong Kong. The former CRC for Beef Genetic Technologies used genomics to improve the quality of beef export products and secure new markets in Asia, and the Sheep CRC has made Australian lamb a premium product.

The Desert Knowledge CRC, which transitioned into the CRC for Remote Economic Participation (CRC-REP) and its research consultancy Ninti One, also worked on developing primary industry opportunities for Northern Australia that could benefit Indigenous communities. These include precision pastoral management technologies, potential bush food industries and barramundi aquaculture.

The Asian Development Bank estimates that Asia will account for almost half of the world’s economic output by 2050, and there will be strong global competition for the region’s markets and investment. Australia currently accounts for only 5% of global food trade, although our food exports are worth more than $30 billion a year. At current production levels, we could supply around 2% of Asia’s food requirements. But could we increase that figure significantly if Northern Australia was developed to grow, and transport, more crops for Asian markets?


IN 2014, THE COALITION government commissioned a White Paper on Developing Northern Australia – an area north of the Tropic of Capricorn stretching around three million square kilometres across Western Australia, the Northern Territory and Queensland.

A decade ago, agricultural production in Northern Australia was worth around $4.4 billion a year, and was dominated by beef, sugar and bananas. By 2010, this grew to $5.2 billion – around 11% of Australia’s total agricultural production – and included crops such as guar beans, chia, chickpeas, soybeans and wild rice.

In a submission to the Federal Government’s National Food Plan Green Paper in 2012, Australian-owned company SunRice emphasised the critical role of water in food production.

“This is a huge opportunity… with combined two-way goods and services trade worth more than $100 billion.”

“Australia’s food security is directly related to water security,” the SunRice submission said. “At the peak of the recent drought when water allocations to rice farmers were reduced to almost zero, rice production in Australia fell from an annual average above one million tonnes to just 19,000 tonnes. This level of production was far short of meeting even our domestic needs, and is a prime example of the importance of water in growing food to feed our nation and others.”

Rice is being grown again in the Burdekin region in north Queensland, and there are suggestions that improved genetics and better understanding of the northern climate could secure Australia’s rice industry against future dramatic production losses due to prolonged drought.


AUSTRALIA IS A GLOBAL leader in sustainable rice production, with around 1500 farms in New South Wales and Victoria feeding up to 20 million people a day around the world.

Our rice farmers are the world’s most water efficient, using 50% less water than the global average to produce each kilogram of rice. They were also Australia’s first farm sector to develop a biodiversity strategy and a plan to reduce greenhouse emissions.

shutterstock_27665581

Australian-owned company SunRice submitted a statement to the Australian Federal Government emphasising that our future food security relies on the availability of water.

Rice was an early, and enduring, success story for the CRCs. The CRC for Sustainable Rice Production started in 1997 at the Yanco Agricultural Institute, near Leeton in the Murrumbidgee Irrigation Area, and concluded on 30 June 2005. It is a classic example of how a CRC can fast-track research results by working with partners in academic research, industry, government and – in this case, specifically – rice research colleagues in China and Japan. In just over seven years, the CRC’s many achievements included better pest controls, improved plant breeding systems, better milling and drying techniques, sustainable irrigation levels, a groundwater management program that was adopted as a UNESCO benchmark, new rice-based food products, and an assessment of salt tolerant wild rice varieties that could be grown in Northern Australia.

In 2003, the CRC’s director Dr Laurie Lewin was awarded one of Australia’s most prestigious science awards, the Farrer Memorial Medal, for his work with the CRC in breeding new rice varieties that are better suited to Australian conditions. In his recipient’s oration, Lewin stressed the importance of genetics to future global food security.

“Recent improvements in plant breeding have been rapid and it is now an exciting time to be involved in this science,” he said. “The rice genome has been sequenced and breeders now have a range of exciting tools to meet the important challenges. It is only 50 years since the Watson and Crick model for DNA was published, but the new genetics has given access to new tools including genetic markers and genetic transformation techniques.”


THE CSIRO ESTIMATES that the area for potential irrigated agriculture, supported by groundwater, in Northern Australia is between 50,000–120,000 ha. But water is only part of the solution to developing northern agriculture and new markets in Asia.

In a Food and Fibre Supply Chain study with the Australian Bureau of Agricultural and Resource Economics, the CSIRO identified three challenges to expanding agriculture in the north to supply Asian markets: sourcing capital investment, cost-efficient production and supply, and establishing new and viable export markets.

GrowNORTH is a research and development consortium that evolved from a Federal Government pledge to develop a northern agriculture CRC, prior to Macfarlane and Prime Minister Tony Abbott announcing plans to create five Industry Growth Centres under the Industry Innovation and Competitiveness Agenda.

“The north isn’t likely to become Asia’s food bowl, but it has the potential to become a reliable and important exporter of high quality food and seriously smart research skills.”

GrowNORTH CEO Mike Guerin says that harnessing the economic potential of the north proved to be “a wicked problem” – a social planning term that means there are complex and often conflicting interdependencies – in the past, chiefly because of “imposed ideas” that ignored geographic, social and climatic differences.

“Large-scale agriculture in the north is a high risk investment, and there have been failures in the past largely because of inadequate planning, financing and management. There’s also been a tendency to ignore, or attempt to work against, what makes the north a unique region,” he says.

“Sustainable development in the north is possible, but it must benefit all Australians. It can’t be viewed as a kind of frontier goldrush for lucrative Asian markets. The north isn’t likely to become Asia’s food bowl, but it has the potential to become a reliable and important exporter of high quality food and seriously smart research skills.

“If we get it right – and we accept that we will need to take the time, resources and patience to do that – Australia can gain a global reputation for using transformative research and economic modelling to create a world-class example of sustainable regional development.

“We will be a world leader in sustainable development, and researchers will come to the north to see how it’s done.”


GUERIN SAYS RESEARCH must look at “bigger picture” issues
in the north, rather than narrowly focusing on advancing single industries.

“We need to look at infrastructure, community support, building a skilled workforce that lives in the north, environmental outcomes, competing land uses and ways that agricultural diversity can benefit local economies,” he says.

“It’s a huge undertaking, and there will be valuable lessons along the way, but the benefits will be significant.”

Rod Reeve, managing director of the CRC-REP, says that building
robust local economies across remote areas in the north is vital to the region’s development. The CRC is working on plans to create more than 100 new Aboriginal and Torres Strait Islander businesses in the north over the next decade, as well as more than 1200 small-to-medium enterprises.

It also aims to increase the productivity of remote pastoral
industries by around $300 million, and has developed a technology that could revolutionise the way cattle are managed in rangelands across the world. Reeve explains this technology as a remote sensing system that allows pastoral station managers to track and weigh cattle at watering points across a huge area, and to manage nutritional feeding programs.

“It’s an innovative system that gathers data on things like the numbers and profiles of the herd, conditions for market, growth rates and whether cows are pregnant or dry,” he says.

“All this can be done remotely, and potentially could replace the expense of aerial mustering which stresses cattle and makes them lose condition.”

The technology was developed by Ninti One and is in the final stages of a pilot study prior to commercialisation and local manufacture.

“We’re hoping it can be manufactured in Alice Springs,” says Reeve. “All the technology has been tested and developed in remote areas in the north, so it would be great to see its commercialisation go on to benefit a local economy.

Rosslyn Beeby

seafoodcrc.com

sheepcrc.org.au

crc-rep.com

nintione.com.au

The next 25 years of Australian R&D

Federal cabinet ministers, CRC program leaders and policy experts will discuss the research challenges of the next 25 years in areas such as manufacturing, health, communications and the development of Australia’s north next week as part of the Australia 2040 forum.

The designs, products and services developed by CRCs are part of our everyday life; from soft contact lenses and tooth mousse that helps repair dental enamel to new materials for aircraft wing surfaces that reduce fuel use and cut global carbon emissions. In food alone, CRCs have transformed the quality of Australian lamb, assessed salt tolerance in rice, improved the health of commercial pig herds, and developed new strategy for fisheries in the face of rising ocean temperatures.

The CRCs were established in 1990 to bring scientists and industries together to work on some of the biggest challenges facing Australia. These have included better bushfire science, manufacturing, digital technology, biosecurity, sustainable farming, water management and mental health issues underpinning the unacceptably high suicide rate among young people.

“The CRCs are an Australian success story. They were designed to create research impact, and their 25 year record of achievement speaks for itself,” says CRC Association chief executive Dr Tony Peacock.

“It’s a unique program and it works equally well across economic, social and environmental research areas. The critical factor in their success is that each CRC has well-defined goals and their management, research and industry investors all agree on those goals and work toward them.”

Peacock says economic analysis has shown that while the CRCs represent less than 1.6% of Federal science funding, they drive a further $4 in investment for every dollar invested by the government.

“The CRCs have always aimed for what is now recognised as vitally important to Australia’s future – creating research impact,” he says.

The CRC’s annual conference will open on 25 May, with former CSIRO chief executive Megan Clark delivering the Ralph Slatyer address on science and society at the Australian War Memorial theatre.

On 26 May, there will be a one-day forum at Parliament House, where speakers will include Federal industry minister Ian Macfarlane, communication minister Malcolm Turnbull and CRC leaders Dr Jane Burns (Young & Well CRC), Professor Mike Aitken (Capital Markets CRC) and Professor Murray Scott (CRC for Advanced Composite Structures).

Details of the conference program can be found at http://australia2040.com.au/

Drone used to drop beneficial bugs on corn crop

Photograph courtesy of Ausveg and Vegetables Australia

During his Summer Science Scholarship at UQ, Mr Godfrey investigated if drones could be used to spread the beneficial Californicus mite, a predatory mite which feeds on pest leaf eating mites onto crops infected with two spotted mites.

Godfrey said two spotted mites ate chlorophyll in leaves, reducing plant vigour and crop yield.

“As corn grows, it is very difficult to walk between the crop to spread beneficial bugs,” he said.

“A drone flying over the crop and distributing the insects from above is a much more efficient and cost-effective method.”

Godfrey began his project at the Agriculture and Remote Sensing Laboratory at UQ’s Gatton Campus, learning how drones function, before spending time at Rugby Farms to gain insight into potential uses for drones.

“I built a specific drone for the project, tailoring the number of propellers, stand, and size of the motor to suit the drone’s application,” he said.

“My initial concept for the ‘Bug Drone’ came from a seed spreader, and in the end I built an attachment to the drone that can be used to spread the mites over the crop from the air.”

2015-04-29_1605Initial designs using a cylinder-shaped container to hold the mites weren’t practical as it couldn’t hold enough of the predatory mites to make the process efficient.

“I used corflute material to make a large enough storage device for the mites,” Mr Godfrey said.

“The seed spreader then acts as the distributer as it has a small motor powering it.”

The device is controlled remotely from the ground.

“We’ve tested the product at Rugby Farms and I’ve successfully proved the concept that drones can be used to spread beneficial bugs,” Mr Godfrey said.

“There is still a lot of work to be done, but the most difficult part is to work out how to control the volume of bugs being distributed at the one time.

“The next step is to monitor the crops and to see what happens after the bugs have been dropped.

“Remote sensing with precision agriculture is an interesting field, and it has opened my eyes to the career opportunities in this field,” he said.

Students can study precision agriculture at The University of Queensland Gatton in a course run by Associate Professor Kim Bryceson who also manages the Agriculture and Remote Sensing Laboratory.

Eyes on the ground

Dog ‘Facebook’ to manage Aussie pest problem

Facial recognition technology is  being used by the Invasive Animals CRC  to identify, track and control  wild dog populations, which cause  significant damage to Australian farms.

Facial recognition technology is being used by the Invasive Animals CRC to identify, track and control wild dog populations, which cause significant damage to Australian farms.

It’s estimated that wild dogs cost Australian farmers more than $65 million each year – a small part of the estimated $1 billion annual price of animal pests to agriculture. Pest monitoring is an important part of ensuring control strategies are effective, and automated technologies that promise more efficient and detailed monitoring are under investigation.

Southern Downs Regional Council in Queensland is working with Australian agricultural tech company Ninox Robotics to spot wild dogs and other pests in their region. The project involves using unmanned aerial vehicles (drones) equipped with thermal imaging cameras, which can map dozens of square kilometres of countryside in a few hours.

The Invasive Animals CRC (IA CRC), NSW Department of Primary Industries and CRC partners have developed camera trap technology with facial recognition software – similar to that used by Facebook to tag your friends – to identify individual dogs and help combat the wild dog problem. Initial tests in northern NSW were able to pinpoint individual dogs with 87% accuracy. The researchers are seeking further funding to turn the technology into user-friendly software for widespread use.

Future versions could monitor other pests including feral cats, and threatened species, says IA CRC researcher Paul Meek. “Technology is providing us with new opportunities to carry out research and management,” says Meek. “And it’s already changing the way we do things.”


Drones streamline cattle musters

iStock_000035347982_LargeMustering cattle on large Australian stations is a time consuming, expensive and sometimes dangerous operation. Before mustering can begin, graziers need to locate livestock using helicopters, horses, quadbikes and motorbikes, sometimes setting up remote camps.

By mapping the cattle’s location, drone technology under development by the CSIRO could potentially halve mustering costs, says project leader and farming systems specialist Dr Dave Henry. Using an off-the-shelf drone and thermal camera, the researchers accurately located cattle on the Lansdown Research Station near Townsville in 2013, and they are seeking funding for large-scale trials – the next step towards a marketable product.

“Technology is providing us with new opportunities to carry out research and management.”

Using sensors, drones could also monitor feed in paddocks, optimising animal production and minimising environmental impact. “Ultimately, graziers and land managers could manage cattle and their environment, and their whole farm business, in a more precise, timely and informed manner,” says Henry.


Satellites drive precision tractors

Precision agriculture uses sensing technologies, from satellites to drones, to help automate tasks like sowing and harvesting. The benefits of satellite positioning in agriculture are substantial, with an analysis by Allen Consulting predicting it will pump up to $28 billion into the Australian economy by 2030.

Improved satellite positioning in agriculture will yield greater navigational accuracy for unmanned farming vehicles such as drones and automated tractors.

Improved satellite positioning in agriculture will yield greater navigational accuracy for unmanned farming vehicles such as drones and automated tractors.

A collaboration including the CRC for Spatial Information (CRCSI) and the Japan Aerospace Exploration Agency has developed positioning technology for a driverless tractor using GPS and the Japanese Quasi-Zenith Satellite System (QZSS). In summer trials in the Riverina, NSW, the tractor navigated rows of crops to an accuracy of 5 cm.

Existing technologies rely on mobile phone coverage and a costly, dense network of ground-based antennas called reference stations. These improve the accuracy of the machinery’s satellite-derived position from several metres to a few centimetres.

But mobile coverage and expensive antennas “are barriers to adoption in remote Australia,” says Dr Phil Collier, CRCSI research director. The researchers’ alternative requires fewer reference stations, instead transmitting position corrections to the tractor via a satellite communication channel unique to QZSS. This approach promises multiple benefits for farmers in remote areas.
Traversing the same ground each time, the tractors use less fuel and reduce erosion. The day may even come where fleets of robotic tractors work overnight, says Collier.


Managing bushfire threat

Automation can also play a major role in predicting and managing the threat of bushfires. Typically, emergency services and researchers rely upon observations by satellites, from aircraft and on the ground.

Drones could provide valuable extra data, says Dr Thomas Duff, a Bushfire & Natural Hazards CRC researcher at the University of Melbourne who specialises in simulations that predict fire behaviour. In contrast to helicopters, unmanned vehicles eliminate risks to pilots, and are cheaper and more manoeuvrable, enabling more detailed observations.

With Country Fire Authority Victoria, researchers at the CSIRO
are using drones to make observations of controlled fires for use in bushfire simulations. The RISER (Resilient Information Systems for Emergency Response) collaboration based at the University of Melbourne is monitoring grasslands to better understand how they dry out each year. Duff says this research is critical to more accurate predictions of fire behaviour.

invasiveanimals.com

crcsi.com.au

bnhcrc.com.au

Cell manufacturing links research and industry

CEO of the Cell Therapy Manufacturing Cooperative Research Centre (CTM CRC) Dr Sherry Kothari said it puts promise in what she believes is the future of medicine.

“One of the biggest advantages that cell therapy holds is that it has the potential to cure. So with drugs and pharmaceuticals you tend to manage and treat conditions but you can’t generally cure them,” Kothari said.

“So the stem cell will go into the wound and it will dampen down any immune response and any inflammatory response to try and get the wound into a state where the normal skin cells can take over the healing process.”

CRC Partner the University of South Australia has a team currently working on a patch that will help cure chronic wounds.

Cell TherapyProject Leader Dr Louise Smith said chronic wounds affect sufferers for years, and sometimes decades.

“One of the ways we’re looking at healing it is by delivering stem cells to the wound to try and help it heal,” Smith said.

“So the stem cell will go into the wound and it will dampen down any immune response and any inflammatory response to try and get the wound into a state where the normal skin cells can take over the healing process.”

img - industries_health_150305_Cell Therapy_banner-2
The CTM CRC.

Chronic wounds are a burden to patients and healthcare systems as they are expensive and persistent, and without treatment can lead to extreme procedures such as amputation.

Around 450 000 Australians are affected by chronic wounds, while the US government spends an estimated $25 billion per year on treatments.

Smith said the project would not have worked without the CRC pulling everything together.

“We wouldn’t have access to the specific cells, we wouldn’t have access to the companies that we’re working with, and we wouldn’t have access to the clinicians and the cleanroom facilities,” she said.

The CTM CRC takes a promising cell therapy, finds an appropriate industry partner and facilitates the therapy through the manufacturing process until it’s ready for use in patients.

Kothari said academic researchers often struggle to source funding for their projects without industry partner collaboration.

“It’s what I and many others describe as the valley of death,” Dr Kothari said.

“You’ve got your academic research which stops at a certain point and then you’ve got the big companies, but often that research is still too early for them to invest in.

Chair of the CRC’s board Dr Leanna Read said bringing down costs is crucial to the future of medicine.

“There’s always a pressure on medicine because the health system is getting more and more expensive,” Dr Read said.

“If you can bring down the costs of producing the cells you’ll be able to expand opportunities for use in clinical practice because they’ll be affordable in mainstream medicine.”

The Cell Therapy Manufacturing CRC is the only one of its kind in Australia and one in a small handful of facilities around the world.

In an effort to build up a global presence in the growing industry the centre has recently formed collaborations with two cell therapy and regenerative medicine institutions in Canada and the UK.

“We have a lot of intellectual capital and know-how here in Australia and South Australia,” Kothari said.

“What we have here is this critical mass, the expertise, the know-how and the infrastructure, so we’ve got a real chance to make it work, to put South Australia on the world stage when it comes to the development of cell therapies.”

This article was first published in The Lead.

3D body scanning helps build fighting force of the future

The $1 million project run the University’s School of Health Science uses ‘digital anthropometry’ to customise the internal specifications of Navy submarines and ships, and to improve the design of uniforms and specialist clothing.

The population is generally taller and wider than they were 30 years ago and lead researcher and senior lecturer Dr Grant Tomkinson says the data will inform decisions around working environments such as the height and width of doorways and the length and width of bunks in submarines.

“Submarines are built to last across many generations, 20 to 30 years or more,” Dr Tomkinson says.

“So while we have a piece of machinery that can last for many decades, the average sailor – just like the average person – is changing over time. People are now on average about an inch or so taller, and a bit wider, than they were 30 years ago.

“It is a way of surveying body size and shape for the Navy which will give them some good predictions on how they might change in the future, and then how their equipment and machines should look.”

Dr Tomkinson and colleague Dr Nathan Daniell are working with a team of postgraduate and undergraduate students to measure 1500 Navy personnel based in New South Wales and Western Australia.

“Our survey of body size and shape uses both traditional methods and a digital approach,” Dr Tomkinson says.

“We use a 3D whole-body scanner, which is like stepping into a large changing room and 15 seconds later we get a 3D image of your body that we can extract measurements from at a later stage.

“It captures about half a million data points on the surface of the body and then we can measure dimensions like waist circumference without needing the person again in the future.”

Dr Tomkinson says the team is contracted to take about 90 measurements of the body, including standard measurements like circumferences, heights, lengths and breadths of the arms, legs and torso.

“We’re also doing some customised measurements such as eye spacing to help viewing through periscopes, head measurements for helmet fit, hand length to navigate controls, and the length from the knees to the buttocks to help with seating size,” Dr Tomkinson says.

“If you’re not fitting in your environment well, you’re not going to be as efficient and it will create more stress and strain. You’re more likely to have more niggles, and those niggles can lead to injuries. The main driver behind this research is ergonomics – to optimise the fit of the person to the environment, help them work better and ultimately build a stronger defence force.”

Captain (Dr) Simon Reay Atkinson said the Royal Australian Navy and the Australian Defence Test & Evaluation Organisation (ADTEO) are collaborating with UniSA and DSTO in the research to solve real-world Defence problems.

“We live in a world in which we can no longer isolate the information from the technological from the human. In this world we need to better fit our people to the work spaces and organisations they occupy, such as operations rooms, so they can solve pressing problems, healthily and over prolonged periods away from Base Ports,” Captain Atkinson says.

This article was first published in The Lead South Australia on 16 April.

Cooking with gas

Wholesale natural gas prices – driven largely by demand in Asia – are more than double the prices modelled by many economists back in 2011. And while the Australian government has applauded the booming Liquefied Natural Gas (LNG) industry in Queensland in its energy green paper for becoming the “first in the world to bring onshore coal seam gas [CSG] to export markets”, this development will see domestic gas prices increase significantly.

“There was this view that we would have a gas boom like the US did,” says Professor Chris Greig, Director of the University of Queensland’s Energy Initiative. “That’s not a reality… It’s too expensive in Australia and the value opportunities are too significant in Asia. The nature of most gas developments in Australia is going to be such that we’re never going to have an abundance of super cheap gas that can realistically compete with coal.”

Yet investment in the sector is booming. According to the energy green paper, almost $200 billion in capital investment has been committed for new LNG projects across Australia.

Petroleum engineer Brian Evans from Curtin University in Western Australia expects that CSG will be produced and used for electricity for the next 30–50 years – and possibly longer given the number of untested basins.

From an emission-reduction standpoint, shale gas is the preferred option. It’s much deeper underground than CSG, which means extraction is less likely to affect shallow groundwater tables. And the process by which shale is deposited doesn’t create carbon dioxide, meaning when the gas is burned, there is next to no CO2 emitted. “The production of shale gas in the US has single-handedly reduced the country’s greenhouse gas outputs,” says Evans.

Australia boasts enough discovered shale gas reserves to easily power the country at its current population for the next 100 years – possibly up to 300 years as the potential to recover more gas improves. Evans expects it will be at least 10–15 years before shale gas is making any real impact to Australia’s electricity generating capacity because of the costs associated with extraction and set-up, as the gas is located in remote regions where there’s no infrastructure, such as pipelines and roadways. The mission of the Energy Pipelines CRC, set up in 2010 and with an additional five years of funding to date, is to facilitate such an expansion by supporting the energy pipelines industry within Australia.

In order to deploy any of these technologies, develop a new gas market, or assist the transition toward renewables, Greig says the government needs to incentivise the corporate sector to invest on projects with 40–50 year outlooks.

“What we’re seeing from government is very short-term decision making,” he says. “Somewhere in government, someone needs to develop a long-term vision for the energy sector, and the electricity sector, which has bi-partisan support. And only then can we build policies that enable us to move toward that long-term vision.”

Roll of the DICE

A report by the Climate Council, an organisation reconstructed through crowd funding from the abolished Climate Commission, suggests that by 2030 more than 65% of the country’s coal-fired power stations will be more than 40 years old. These will need to be either retired or replaced.

In an opinion piece for Business Spectator, Climate Council executives Tim Flannery and Andrew Stock suggested this is “the ideal time to begin phasing out inefficient power stations and fundamentally rethinking our energy system” by ramping up our renewable energy generation and storage capacity.

“A well-conceived energy policy for the electricity generation sector would see ageing, low-efficient plants replaced with high-efficiency ultra-supercritical [coal] plants,” says Professor Chris Greig, Director of the University of Queensland’s Energy Initiative.

These plants have lower emissions simply by virtue of their efficiency, and could achieve emissions reductions of 25% compared to existing plants, says Greig.

Another option in reducing emissions and continuing to rely on coal is to replace ageing power plants with smaller, modular facilities that use a technology called the Direct Injection Carbon Engine (DICE). First demonstrated by US engineers more than 20 years ago, the DICE is a modified diesel engine that can generate electricity by burning coal that has been finely ground-up and mixed with water.

With the DICE, air is compressed inside a cylinder by a rotating piston. As the air is being compressed, the slurry is directly injected into the chamber at a precise moment.

The heat of the pressurised air causes the slurry to combust and the intense heat and pressure inside the engine creates mechanical energy, which can drive a turbine and generate electricity.

This is similar to the way heavy fuel oils are injected into conventional diesel engines on transport trucks, and ensures good control over the heat release rate, as well as high-efficiency combustion of slurries made from varying qualities of coal. Carbon capture systems can also be integrated onto the engines to minimise emissions.

The CSIRO has developed methods to produce more cost-effective fuels that work inside much larger engines. Their work has sparked renewed interest in DICE systems for a range of electricity generation applications.

Louis Wibberley, the principal investigator, says DICE systems are more efficient than conventional coal-fired power stations and can achieve up to 40% emissions reductions with black coal, and up 50% reductions with brown coal.

– Myles Gough

Uncovering healthcare cons

Supported by new funding available from 1 July 2014, the program will operate three streams to explore and compare huge datasets available in the healthcare sector. The goal is to make improvements to the detection and management of fraud, consumer choice and data management.

The CMCRC is adapting one of its existing analytical solutions, I+Plus, to analyse and cross-reference the many disparate sources of information available in healthcare. It’s hoped this tool could prove useful for healthcare providers to compare their performance with competitors by using industry benchmarks once they are developed.

The CMCRC hopes to have the first results of its new research initiative into healthcare by the end of this year, said Chief Operating and Commercial Officer, David Jonas.

Jonas, who is also CEO of the organisation’s health insurance spin-off company, CMC Insurance Solutions, said the new research program is a natural extension of the group’s work into health insurance.

“It’s broadened out in the past two years to the whole of health,” he explained.

Although it’s a foray out of capital markets for the CRC, success in identifying fraud in the health insurance market, along with a raft of other achievements, led the centre to investigate the detection of similar inefficiencies in the provision of health in general.

The CMCRC will receive $32 million in funding through round 16 of the Australian Government’s CRC Program. About 40% of that will be going into the new health market quality program.

Industry partners already signed up by the CRC include 29 private health insurers, the National Health Performance Authority, NSW Health, and the Victorian Government’s WorkSafe and TAC (Transport Accident Commission) compensation schemes.

“We don’t yet have a public health insurer as an industry partner, but we are gradually engaging with Medicare and the Department of Veterans’ Affairs,” Jonas said.

The new program’s first initiatives will identify the metrics required for assessing market integrity and efficiency. The research will then look at what data needs to be gathered to generate those metrics and how such benchmarks can be used to find solutions.

The centre is already engaging in a range of small start-up projects with all of its industry partners. Jonas pointed out that one of the main difficulties with the healthcare industry is the fragmentation of data, with diagnosis and treatment records for patients being distributed across multiple healthcare providers and funders.

But if healthcare is looked at as a market, rather than a system, it could be easier to identify inefficiencies and then achieve efficiencies.

“Part of our program is to assure market quality in healthcare for providers and users,” Jonas said.

Penny Pryor

www.cmcrc.com

Virtual dentistry for remote Australia

The trials, which explored the application of ‘teledentistry’, were developed by the Oral Health CRC, the University of Melbourne’s Institute for a Broadband-Enabled Society and dental specialists at Melbourne’s Royal Children’s Hospital. They are supported by Google.

The project’s research leader, Associate Professor Rodrigo Marino, said the system could help improve dental health for Aboriginal children in remote communities. A pilot program is also exploring the use of teledentistry to provide dental services and oral healthcare treatment plans for elderly patients in nursing homes.

Pneumonia linked to oral infections is a major cause of hospitalisation among older people, and can be fatal. “Residents in nursing homes often don’t have access to dental services,” Marino said. “But with teledentistry, a consultation could be done by the nurses, with minimal disruption or discomfort for elderly patients.”

The CRC’s teledentistry trials involved consultations with 43 children in Geelong, Shepparton and Rosebud in Victoria. Three dentists in these regional towns were trained to use intraoral dental cameras to enable Royal Children’s Hospital orthodontists and palate specialists to conduct virtual examinations via real-time video.

No special software or equipment needed to be developed for the trials. CRC researchers used a computer equipped with sufficient memory to handle real-time video processing, a web camera for video conferencing and an intraoral camera about the size and shape of an electric toothbrush. They found that video streaming at a minimum of 3 Mb/s and internet bandwidth of 5 Mb/s provided good quality images for the dental specialists to analyse.

“We could see images in real time on the screen during the consultations, and the remote area dentists and the specialists in Melbourne could collaborate to work out a treatment plan for each patient,” said Marino.

Of the trial consultations, 57% resulted in treatment advice that meant patients could avoid a time-consuming trip to Melbourne. Marino said teledentistry will eliminate the time and expense incurred by rural patients, who often face a long, exhausting drive with no guarantee of an immediate and direct benefit.

He said the promising results show teledentistry could play a vital role in providing affordable and timely dental healthcare for urban Australia as well as rural and remote populations.

“It can increase access to specialist care and it can screen patients to make sure that only those who need to see a specialist will be put on waiting lists,” Marino explained. “So, it also has the potential to reduce the waiting time for treatment.”

Rosslyn Beeby

www.oralhealthcrc.org.au

Alzheimer’s Disease drug discovery gives hope

Scientists from the University of South Australia, along with colleagues from Third Military Medical University in Chongqing, China, have discovered the drug Edaravone can alleviate the progressive cognitive deficits of Alzheimer’s Disease.

Edaravone is used to aid neurological recovery following acute brain ischemia and subsequent cerebral infarction, but is currently available only in some Asian countries.

Lead researcher Professor Xin-Fu Zhou, who is Research Chair in Neurosciences at the University of South Australia, said Edaravone alleviated Alzheimer’s Disease pathologies at multiple levels and improved learning and memory functions in mice.

“Edaravone can bind the toxic amyloid peptide which is a major factor leading to degeneration of nerve cells,” Prof Zhou said.

Prof Zhou said lessons learned from failures of current clinical trials suggest that targeting multiple key pathways of the Alzheimer’s Disease pathogenesis is necessary to halt and delay the disease progression.

“Edaravone can suppress the toxic functions of amyloid beta to nerve cells – it is a free radical scavenger which suppresses oxidative stress that is a main cause of brain degeneration,” he said.

“The drug can suppress the production of amyloid beta by inhibiting the amyloid beta production enzyme. It also inhibits the Tau hyperphosphorylation which can generate tangles accumulated in the brain cells and disrupt brain functions.”

Prof Zhou said that although he didn’t believe Alzheimer’s Disease could ever be cured, the drug was the best hope of attacking the debilitating disease through multiple signal pathways.

The research is a collaboration between Prof Zhou’s lab within the University of South Australia’s Sansom Institute for Health Research and School of Pharmacy and Medical Sciences, and labs led by Prof Yanjiang Wang in Chongqing, China.

The next phase is to seek funding and investment to develop an oral formulae before undertaking clinical trials.

The discovery was published yesterday (7 April) in the Proceedings of the National Academy of Sciences of the United States of America.

First tech-commercialisation skills study funded

The year-long study will be run by Knowledge Commercialisation Australasia (KCA) – the peak body for Australian organisations and individuals in knowledge commercialisation and exchange between public sector research organisations, business and government – and gemaker – a company specialising in commercialising technology.

The key objective of this study is to provide a clear understanding of what it really takes to get new ideas generated by Australian publicly funded research organisations into society and the marketplace.

To kick start the project and help consolidate the study’s framework, a series of workshops will be hosted across five states between April and June. Technology transfer practitioners and industry stakeholders will be invited to participate in these workshops, offering both individuals and institutions an exclusive opportunity to help shape the future direction of professional development within the sector in this country, and provide foresight as to the true nature of the skill set required to effectively undertake this role going forwards.

 “There is an increasing expectation from government entities within Australia for publicly funded research organisations to improve on the conversion of research into commercial outcomes. Much like the theme of our forthcoming conference – Raising the Bar – this study will enable us as a community of practitioners to look strategically at what it means to be a commercialisation professional at a research organisation in Australia, and how we might look to improve upon how we go about our practice. We are thrilled to be awarded the Professional Standards Research Grant,” KCA Executive Officer Melissa Geue said.

KCA applied for the research grant in partnership with technology commercialisation consultancy gemaker (associate member of KCA) in late November 2014. The project team is being led by gemaker’s Commercialisation Director Athena Prib, RTTP and will be comprised of gemaker’s team of specialists in capability development and workplace competencies, as well as KCA’s Executive Officer, Melissa Geue and Vice Chair and Professional Development Leader, Dr Alastair Hick (also Director of Commercialisation at Monash University).

“We are excited to be leading the first project of its kind that will open the door for the research and commercialisation sector to connect and self reflect, and we hope this study offers a baseline for our association, KCA, to build on for years to come,” said Natalie Chapman, gemaker’s Managing Director.

Overall the study will provide insight into the different technology transfer models used across Australia and the mechanism used to equip people with knowledge of skills required by industry and research. The primary goal is to look at the skills and competencies required on both the research and business side, to undertake a skills gap analysis, and to begin to assemble a framework for professional development across the Australian research commercialisation sector.

“Knowledge exchange and commercialisation is an important area of innovation for Australia and building standards and professionalisation options for the industry is an opportunity to cement Australia’s leadership,” said Dr Deen Sanders, PSC Chief Executive Officer.

“Our role is to encourage professional standards and consumer protection and so we are pleased to support the research and commercialisation sector in taking a serious and strategic approach to building a profession in this area.”

IP fund boosts commercialisation

The unique Intellectual Property Management Initiative offers grants to initiate patent protection of inventions stemming from biological research at South Australia’s three main universities – The University of Adelaide, Flinders University and University of South Australia.

Dr Stefan Enderling, the business development manager at Bio Innovation SA, said the initiative is funded by the Government of South Australia and managed by Bio Innovation SA to help pay for the first stages of the patenting process.

“This provides the institution with a dated ‘peg in the ground’ relating to their intellectual property, and gives them an asset with which to undertake economic development,” he said.

A patent is a right granted for a device, substance, method or process that is new, inventive and useful when compared with what is already known. It gives researchers an exclusive right to commercially exploit an invention.

In Australia, patents are administered through IP Australia and the first step in the process is applying for a Provisional Patent.

The 2011 commencement of the Intellectual Property Management Initiative is linked to a 90% increase in the filing of provisional patents from South Australia’s universities.

“It’s been a very successful program,” said Dr Enderling. “The filing of provisional patents increased from 57 during the 2008–2011 period, to 109 in the years 2012–2014.”

The rapid impact of the initiative illustrates the highly targeted nature of budgets within research environments.

Costs of provisional patents are usually in the range of AUD$4000 to $7000, but can be as high as AUD$10,000 for more complex technologies. Further patenting and searching across international databases attracts additional costs. Typically, institutions do not have funds set aside to cover these expenses.

“Universities have scarce resources that have to be diverted towards specific purposes,” said Dr Enderling. “In the past, this meant that patenting was often pushed to the side.”

Biological sciences patent attorney Mark O’Donnell said the Intellectual Property Management Initiative has nudged more South Australian researchers towards protecting their ideas.

“In the scheme of the cost of the research, four to seven thousand dollars doesn’t sound like that much,” he said. “But it’s a big expense for a university to take on, so having this fund is a fantastic thing for them.”

“Previously – because of the lack of funding – provisional patents just weren’t being filed, so research never had that chance of being commercialised.”

“I have not heard of any other comparable programs across Australia,” said O’Donnell, a partner at patent and trade mark attorney firm Madderns in Adelaide, South Australia.

The Intellectual Property Management Initiative has provided support for 78 projects since 2011 at the University of South Australia. The university’s technology commercialisation company ITEK Ventures Pty Ltd has filed 67 new patent applications in that period.

One of ITEK’s projects to benefit from the initiative is the Hand Held Cancer Probe, an ultrasensitive magnetic probe which detects small amounts of clinically introduced magnetic material in lymph nodes. The probe offers a non-radioactive approach for mapping the spread of cancers.

“The Intellectual Property Management Initiative covered the costs of filing the provisional patent, the International Type Search Report and the PCT application associated with this technology,” said Dr JC Tan, Commercial Manager at ITEK Ventures Pty Ltd.

The PCT application provides the university with patent protection in 148 countries, and expands the time frame for investigating market potential.

“Although the Hand Held Cancer Probe project has not yet been licensed, we are currently talking with Australian and international industry about this technology,” said Tan.

This story first appeared in The Lead, South Australia: bit.ly/1INzUFy

JCU develops new standard for life jackets

surf2Researchers led by Wade Sinclair from JCU’s department of Sport and Exercise Science were given a clear brief – the vests must return an unconscious swimmer to the surface and not inhibit lifesaver tasks such as diving and swimming.

The testing found that full-sized lifejackets compliant with Standards Australia’s rigorous Level 50 standard were unusable in heavy surf. Their buoyancy and impact levels from waves were too high, making their use by lifesavers exhausting.

The JCU team tested low buoyancy devices and found they could be used more comfortably in the surf, but still reliably return a swimmer to the surface.

With no Australian Standard in place for low buoyancy devices, the JCU team conducted research, trials and analysis around Australia and then wrote a report for the SLSA and Standards Australia.

The low-buoyancy, high performance vests are designated as Standards Australia Level 25 – suitable for users such as wakeboarders and surfers who need to remain agile but also face the risk of becoming disabled in the water.

Manufacturers have used the new standard to produce ten prototype life vests. JCU is now testing them in different conditions around the country.

Anthony Bradstreet from SLSA said the organisation’s board will receive the final report on the JCU trials in May. “We need to be sensible and take a risk-based approach,” he said. “I don’t think it is going to be necessary for competitors to wear these vests in flat conditions, but their potential use in rougher conditions will still be a fairly large cultural shift.”

Mr Bradstreet said SLSA wanted JCU to produce a specification, rather than choose a specific product, as that approach would ensure multiple suppliers and encourage ongoing innovation.

He said JCU won the contract to do the testing over bigger organisations for a number of reasons. “We were aware of Wade Sinclair’s work in surf sports and he had gathered a group of very keen and eager research assistants around him. There is a lot of respect for JCU’s Sport and Exercise Science department,” he said.

*SLSA has more than 160,000 members

*About 60,000 are ‘nippers’ – children aged 5 to 13-years-old.

*The vests are expected to cost between $150 – $200

Science’s $145 billion value

A report released today has found that advanced physical and mathematical sciences make a direct contribution to the Australian economy of around $145 billion a year, or about 11% of GDP.

When the flow-on impacts of these sciences are included, the economic benefit expands to about $292 billion a year, or 22% of the nation’s economic activity.

Prof.Ian_ChubbThe report was commissioned by the Office of the Chief Scientist and the Australian Academy of Science and produced by the Centre for International Economics (CIE).

“For the first time we now have the numbers on the table showing the importance of these sciences to the Australian economy,” Australia’s Chief Scientist Professor Chubb said.

“It is too easy to take the benefits of science and innovation for granted, and this report shows that the knowledge from these disciplines supports and enhances economic activity which benefits all Australians.”

Australian Academy of Science President Professor Andrew Holmes said the report was a significant step in improving public awareness of the economic contributions of Australian science.

“The detailed report carefully maps out the pathways by which advanced physical and mathematical sciences yield economic results,” Professor Holmes said.

The figures in the report are conservative and only include the economic benefits of discoveries and innovations implemented in the past 20 years in physics, chemistry, earth sciences and the mathematical sciences.

The report includes examples of how these sciences benefit the economy, such as advanced mathematics supporting the effectiveness of mobile phones and wireless internet, and sets out a selection of breakthroughs that have had an economic impact.

The report, titled The importance of advanced physical and mathematical sciences to the Australian economy, did not examine the economic benefits of biology and life sciences. The economic impact of these sciences could be assessed in further studies.

A copy of the report can be found at chiefscientist.gov.au and science.org.au/science‑impacts‑economy.

Happy gaming

Young and well CRC researcher Dr Daniel Johnson and his team at the Queensland University of Technology’s Games Research and Interaction Design Lab are exploring positive links between gaming and wellbeing. Johnson completed a year as a postdoctoral fellow at the University of Cambridge Well-being Institute in the UK before returning home to Australia to work at QUT.

“Historically, there has been a huge focus on the potential negative impacts of video games,” says Johnson. “So as a first step, we undertook a large-scale review of the literature relating to the positive impacts.”

In their experimental trials, the team monitor biometrics, such as brain activity, heart rate and muscle activation, in participants playing video games.

They have found clear evidence of a positive link between gaming and self-esteem, optimism and relationships. In collaboration with Smiling Mind, a not-for-profit initiative to engage young Australians in meditation, the results are being applied to improve physical and mental health.

“We are working towards a more broad-ranging view of the potential benefits of gaming and a deeper understanding of what types of games and features of games have a positive influence for which people,” says Johnson.

His overall advice is to “enjoy video games as part of a balanced diet. But think mindfully about what you play, how you play and how it makes you feel.”

Data discoveries

In the environment, big data can be used to discover new resources, and monitor the health of the resources we rely on, such as clean water and air. ANSTO is at the forefront of big data analysis and precision modelling in environmental studies at both national and international scales.

Particle accelerators are used to analyse samples at a molecular level with extremely high precision. At ANSTO, they have been integral to identifying a potential water source in the Pilbara area in northern WA, as well as measuring air quality in Australian and Asian cities.

Despite its remoteness, the Pilbara contains major export centres, such as Port Hedland, which rely heavily on sustainable use of water. In March 2014, ANSTO’s Isotopes for Water project released the results of their investigation into water quality, sustainability and the age of groundwater in the arid Pilbara region, to determine its viability as a future water resource to support the growth of the area.

“A large, potentially sustainable resource was verified by using nuclear techniques,” explains Dr Karina Meredith of ANSTO, who leads the project investigating water sources. “The outcome of this seven-year study provides a greater degree of certainty of water supply for the Pilbara.”

By calculating the age of water, ANSTO researchers can determine whether it can be drawn off sustainably, and where replacement (known as ‘recharging’) will be sufficient to maintain reservoir levels. Levels of carbon-14 in groundwater decay naturally over time, and by measuring minute traces of this radiocarbon in the groundwater with ANSTO’s STAR accelerator, scientists like Meredith can tell how old the water is. “We’ve found it’s about 5000 years old, and what was really interesting is that one of the areas had waters that were approximately 40,000 years old,” says Meredith.

Her calculations show it will be OK to drink the 5000-year-old water, as the reservoir is sufficiently recharged by water from cyclones. The 40,000-year-old vintage won’t be flowing through kitchen taps, however, as this region isn’t recharged fast enough, she says.

190215-ansto-box

ANSTO’s particle accelerators are being used to analyse air pollution in cities such as Manila in the Philippines.

For more than a decade, Dr David Cohen of ANSTO has used the same accelerators to track down the sources of fine particle air pollution in Australian and Asian cities. Air pollution particles come in different sizes, but fine particles are the most damaging to human health – they penetrate deep into the lungs and have been linked to cardiovascular disease.

Cohen is the data coordinator of an international study of fine particle air pollution that takes samples in cities across 15 countries in Asia and Australasia. Combining the fingerprints detected using STAR with wind back trajectories, he’s shown that the air in Hanoi, for example, can contain dust from the Gobi Desert in Mongolia and pollution from Chinese coal-fired power stations some 500–1500 km away.

In addition, to reveal the sources of air pollution nationally, Cohen’s team has recently completed a study of the Upper Hunter region of NSW, which found significant fingerprints from domestic wood burning.

“In winter, up to 80% of the fine particles were coming from wood,” says Cohen. “So the most effective way to reduce winter air pollution would be to regulate burning wood.”

www.ansto.gov.au

Using algorithms to capture risk

IN THE HEALTH SECTOR, big data has been harnessed with remarkable success. One high-profile example is Google’s Flu Trends website, reported in a paper for the journal Nature in 2009 for accurately predicting the spread of epidemics based on the frequency of disease-related search queries.

Associate Professor Trish Williams, who heads the eHealth Research Group at Edith Cowan University in Joondalup, WA, says that unlike a lot of health research, projects using big data don’t focus on ‘cause and effect’. Instead, they tap into the huge potential of predictive analytics.

That’s an area where collaborative research can come to the fore, she says. Williams adds that big data research is most effective when done by cross-disciplinary teams who can both interpret information and present the findings to a broad audience.

“In health, it is really important that the semantics of the data are well-understood before you start analysing things,” she says. “You’ve also got to work out how to use some very big datasets, perhaps in ways that they weren’t necessarily intended to be used.”

“We’re working to improve the algorithms that detect what kind of problem the person has.”

This conundrum is very familiar to Associate Professor Jane Burns, CEO of the Young and Well CRC. When her team compared the results of a national survey that used ‘traditional’ computer-assisted telephone interviews with those from a similar Facebook survey, they expected both datasets would reveal similar trends.

“We found that the results were not similar at all; the internet results showed far higher levels of psychological distress,” she says, adding that there’s no sure way to work out which survey style had less bias. “Possibly, people are far more honest over the internet than they are over a telephone interview.”

Researching suicide indicators in social media is in its early stages, with researchers from the Young and Well CRC working with key industry partners such as Facebook, Twitter and Google.

“We’re trying to understand from a suicide prevention perspective, how we might be able to use big data to understand trends in the way in which people respond to things, to see if we can look to algorithms to capture some of the risks,” says Burns.

Twitter profile on Apple iPhone 5S

Social networking media holds a wealth of information on the public’s mental health.

With more than 500 million short messages going out through the Twitter network daily, Burns says that finding algorithms to uncover keywords for suicide risk is a huge challenge.

Included in the research is suicide contagion – where one suicidal act within a community increases the likelihood of more occurring. Burns says a key focus of their research around suicide contagion, as well as identifying early warning symptoms or signs, is initiating support networks.

Within the Young and Well CRC, Associate Professor Rafael Calvo of the University of Sydney is working to design tools that help moderators in online health-focused communities, such as youth mental health support service ReachOut.com, to provide appropriate feedback and support for their members.

Thousands of forum posts can be automatically processed, generating a report that prioritises more serious problems so moderators can respond immediately. The team has also developed suggested ‘intervention’ templates, which link to helpful resources.

“We have built the interface for the moderator, and we’re now working on improving the algorithms that detect what kind of problem the person has,” Calvo says.

One of the hopes for big data analysis is to uncover measurable biological indicators for devastating mental health disorders.

One of the hopes for big data analysis is to uncover measurable biological indicators for devastating mental health disorders.

Social media is just one of the big data examples in health. At the CRC for Mental Health, researchers are looking for biomarkers – measurable biological indicators that might enable early intervention for people at risk of Alzheimer’s disease, mood disorders, schizophrenia and Parkinson’s disease. Datasets include the Australian Imaging, Biomarker & Lifestyle Flagship Study of Ageing, which has genomic information for more than 1500 people – some with normal cognitive function, others with mild cognitive impairment and others who have been diagnosed with Alzheimer’s disease.

Dr Noel Faux, a bioinformatician at the Florey Department of Neuroscience and Mental Health, says that the vast amounts of information already available include blood measurements of thousands of hormones and proteins. Cognitive and clinical assessments are also being gathered.

His team is working with software developer Arcitecta to help researchers capture clinical data on-site and feed it into a data repository that can be used by multiple research institutions.

www.youngandwellcrc.org.au
www.mentalhealthcrc.com
au.reachout.com

 

Tracking health

HealthTracks, a web-based tool built by the CRC for Spatial Information, has been used by researchers at Western Australia’s Department of Health to merge health data with spatially-based datasets. The aim is to identify populations at risk of disease and gaps in the location of essential health services.

So far, hospital and regional health data has been combined with public datasets via the WA Landgate Shared Land Information Platform. When rolled out nationally, the tool will include modular enhancements for the analysis of mental health, child health and environmental health data.

bit.ly/1klzui7

The data deluge

WHEN A POWERFUL magnitude 7 earthquake devastated the Republic of Haiti on 12 January 2010, more than 200,000 people were killed. Around 3 million people were affected by the earthquake and its aftershocks, which destroyed 250,000 homes and 30,000 commercial buildings.

Around 630,000 people left the chaos of Haiti’s capital, Port-au-Prince, in search of shelter, water and sanitation. Many of these people used Haiti’s four main mobile phone providers, via its 6 million mobile phone lines, to call friends or relatives in rural areas. Those calls enabled Swedish medical researchers at the Karolinska Institutet in Stockholm to track their movements and to identify areas at risk of potential cholera outbreaks.

The researchers worked with Haiti’s largest mobile phone operator, Digicel, to analyse the call history of 2 million mobile phone users, before and after the earthquake. The results, published in PLoS Medicine and Proceedings of the National Academy of Sciences in 2011 and 2012 respectively, found that “people seemed to have travelled to where they had significant social bonds and support”. More specifically, most Haitians fleeing Port-au-Prince went to the same locations where they had spent Christmas and New Year. The study showed that large-scale movements after earthquakes and other disasters are not chaotic, but often highly predictable, and could be used to improve the efficiency of aid distribution.

The Haiti research is an example of how big data analysis can be used for humanitarian purposes or ‘data philanthropy’ in developing countries. A May 2014 report by the Bill and Melinda Gates Foundation suggests that mobile phone data is “one of the only large-scale, digital data sources that touch large portions of low-income populations,” and if analysed “under proper protections and anonymisation protocols, it can be used to enhance the lives of poor people around the world”.

Victims survive in the aftermath of historic earthquake in Port-Au-Prince, Haiti January, 2010

A study of Haitian phone records showed that people’s movements after a disaster are often highly predictable.

MOBILE PHONES ARE just one source of big data in a world where global satellite navigation, online transactions, sensors, digital closed-circuit cameras, radar monitoring and aerial surveys using pre-programmed drones generate hundreds of exabytes (billions of gigabytes) of data a year. In 2010, The Economist published a series of features on ‘the data deluge’, warning that keeping up with this flood was difficult enough, but “analysing it, to spot patterns and extract useful information, is harder still”. A 2011 report by the McKinsey Global Institute estimated that the volume of global data was predicted to grow by 40% a year, but global spending on data information management was growing at just 5% annually. Technology researcher Gartner estimated that big data analytics drove US$28 billion of global IT spending in 2012, and predict expenditure will exceed US$230 billion in 2016.

In Australia, the Data to Decisions Cooperative Research Centre (D2D CRC) has received $25 million from the federal government and $62.5 million from industry and research participants to address big data challenges. It follows a review of the data analytics and management capacity of Australia’s public service, including defence and federal law enforcement agencies.

Based in Adelaide, the D2D CRC will focus on three research areas: data storage and management, analytics and decision support, and law and policy for big data analysis including issues such as privacy. Participants include Deakin University, the Australian Federal Police, the Attorney-General’s Department, the Department of Defence, the University of South Australia, the University of Adelaide, UNSW Australia, BAE Systems and SAS. The CRC will also develop research links with leading US universities and data analysts.

“We’re dealing with vast volumes of raw, unstructured data. For defence and national security, it’s like looking for the proverbial needle in a haystack.”

DR SANJAY MAZUMDAR, the CRC’s chief executive, says the bid to establish the $88 million research venture arose from discussions about future challenges to Australia’s national security and a shortage of skills in data intelligence applications and analytics. Australia urgently needs to build a skilled workforce to manage, extract and analyse data. The CRC aims to produce 48 PhD students across areas that include health care, IT, government services, law, manufacturing and defence intelligence systems. It will also train 1000 data scientists through its Education and Training Program, and work with universities to build on existing degrees in business and data analytics.

Australia’s defence and national security sectors face “the most imminent and complex” challenges from the global data deluge, Mazumdar says. British mathematician and global data analytics expert Clive Humby has described data as “the new oil”, but Mazumdar points out that, like oil, data needs to be processed to extract maximum benefit.

“We’re dealing with vast volumes of raw, unstructured data. For defence and national security agencies, it’s like looking for the proverbial needle in a haystack. In a time-critical situation, you need to be able to extract actionable intelligence from that data, and to do that, you need advanced data analysis programs that can process and filter that data quickly, accurately and efficiently,” he says.

Even when massive datasets have been processed and analysed, there’s still a need to cross-reference and present findings as visualisations – tables, charts, graphs, keywords and heat maps – that condense the data to manageable and easily assimilated information. Otherwise, Mazumdar says, we may be “drowning in data but starved for information”.

He explains that it’s not only defence and national security agencies that will benefit from expanding Australia’s skills in data analytics. “In mining, for example, the biggest costs are around exploratory drilling to obtain samples for analysis. There’s a possibility that geophysical data from satellite images could be used to pinpoint where deposits are likely to occur, and that could be immensely cost-saving.”

Mazumdar says the CRC will provide a variety of big data users – from government departments and utilities to universities and private industry – with the “tools, techniques and workforce to unlock the value of their data to make more informed and efficient decisions”.

Advanced machine learning and data retrieval systems are critical research areas for big data management. Mazumdar uses the example of image extraction during an attempted terrorist attack, when police and defence intelligence may need to analyse hours, days or even weeks of footage from closed-circuit cameras.

“If you can teach a computer to look for certain combinations of things in that high-volume data stream, you will get a faster result that will inform real-time decisions a lot more quickly,” he says.

The CRC will develop next-generation data storage and large-scale processing software from commercial open-source data management systems, such as Hadoop. Mazumdar says new systems of data mining and machine learning could reduce the time required to analyse high-volume data streams, including satellite imagery. It’s not a question of automating decisions via a machine, but of using data analytics to strip out non-essentials and collate relevant material.

“The human eye and brain are very good at processing complex information from images, but they wouldn’t cope with such a high volume of material. If we can teach a computer to look for certain combinations of things, like the shape of an aircraft, for example, the machine can sort the images in the data pipeline into a smaller, more manageable dataset.”

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THE RIGHT TO privacy and debate over who owns data generated by social media, mobile phones, ATMs and iPad apps, is a hotly-contested topic.

A data management issues paper was developed by the Australian Government Information Management Office (AGIMO) to identify and discuss privacy and security implications around the use of government agency data. The AGIMO estimates that 90% of data in the world today was generated over the past two years alone, and that this amount of data will be 44 times greater by 2020. But who should have right to use such data and under what circumstances, and what controls are appropriate to place on its use?

The AGIMO argues that private companies such as banks, online retailers, insurance companies and social media sites, including Twitter and Facebook, harvest huge volumes of customer data, which is analysed and used to create new client services. Government departments and agencies could also use data analytics to improve services, but they’re bound by a range of legislative controls relating to privacy, security and public trust. In Australia, they must obtain and use information according to the Privacy Act, the Telecommunications Act, Freedom of Information laws and others.
The Gates Foundation report gives an example of mobile phone data use that generated controversy. When health researchers at Harvard University obtained Kenyan mobile records to track the spread of malaria in 2012, it provoked a storm of protest from people who had unknowingly contributed to the study. The researchers had obtained anonymised records for every call and text message sent by 15 million Kenyan mobile phone subscribers over a year, and used the data to identify regions where malaria infection had originated to target medical aid more effectively.

Despite the humanitarian nature of the research and reassurances that callers could not be identified from data provided, Kenyan media claimed the study had breached privacy. The Gates Foundation report says the incident shows that “even with the best of intentions and adherence to rules”, researchers need to consider privacy issues when collecting data.

Professor Louis De Koker, of Deakin University’s School of Law, was founding director of the Centre for the Study of Economic Crime at the University of Johannesburg in South Africa. He will lead the D2D CRC’s Law and Policy program, which combines senior law and socio-legal researchers from the Deakin School of Law and UNSW Australia Law.

“Big data analysis challenges existing privacy principles because our current framework is built around the notion that you own your data and anyone who wants to use it needs your consent to do so,” he says. “It also assumes that data can be effectively de-identified, whereas data analytics can now enable re-identification.”

Social network and mobile media concept“In many cases, the data you generate from, for example, activity on social media sites or Google searches, may be analysed and produce more data and a deeper understanding about you or about communities of which you are a member. In addition, that data would often be stored in another country. What are the laws that apply to that secondary data, and how do you enforce any breaches of rights that you may have in relation to that data? How do we harness such data to improve national security while protecting Australians from abuse of their data? Those are the kinds of policy questions that need to be looked at.”

He says privacy concerns reflect a substantial increase in the volume of data being collected and social concerns and fears around being spied on.
“Unlike the days when you filled in a form and physically handed it to someone, people often don’t know what kind of data is being collected, how and when it’s being collected, who is using it to draw conclusions about you or which decisions by government or private companies relating to you are affected,” he says.

“These days, we take the presence of surveillance cameras very much for granted because they’re everywhere – they’re in shops, airports and at ATMs. But what are the implications when we combine these data sources with sophisticated data analysis? How can we harness the benefits of such data and protect society against abuse?”

In 2013, Shoalhaven City Council installed CCTV cameras in the NSW South Coast town of Nowra as part of a crime prevention program. The surveillance cameras were installed in public places, including shops, parking lots and parks. But a resident challenged their use and argued before the Administrative Decisions Tribunal that it was not the council’s role to collect evidence for the purpose of prosecuting crime. The tribunal upheld the resident’s complaint, ruling that council signage near the camera did not adequately inform people about privacy implications. It also ruled that the council had not established that filming people was “reasonably necessary” to prevent crime.

De Koker says there’s also debate around the adequacy of the protection afforded by giving people notice and gaining their consent to collect and use data, for example when customers sign online agreements relating to social media, software downloads and apps. A report to President Barack Obama in May 2014 on big data and privacy by the President’s Council of Advisors on Science and Technology stated that “each individual app, program or web service” is legally required to ask people to give consent for data collection practices. “Only in some fantasy world do users actually read these notices and understand their implications before clicking to indicate their consent,” the report says.

Mazumdar and De Koker say the D2D CRC will explore opportunities and challenges posed by high-volume data harvesting and analytics in consultation with legal and national security experts.

“All governments are grappling with this issue…There is a lot of good that can come from big data analysis, but we need to balance our expectations and concerns,” De Koker says.

“In the modern world, one of the biggest threats to both national security and personal privacy is a person sitting in a room with a laptop.”

THE ADVISORY COUNCIL’S report to President Obama suggests future generations, who will have grown up with digital technologies, “may see little threat in scenarios that individuals today would find threatening”. It describes a future in which “digital assistants”, in the form of data collection cameras, film a woman packing her suitcase for a business trip. The bag is placed outside for pick-up, with her digital assistants sending the delivery instructions. The suitcase won’t be stolen because a streetlight camera is watching it and every item inside it has a tiny electronic tag that can be tracked and found within minutes.

Her world possibly “seems creepy to us”, but she has “accepted a different balance among the public goods of convenience, privacy and security than most people would today,” the report says.

“In the modern world, one of the biggest threats to both national security and personal privacy is a person sitting in a room with a laptop,” says Mazumdar. “That threat will only grow as the world becomes increasingly reliant on digital technology. We’re already detecting sophisticated ways to hide data and connections online. We need to improve our national capacity to detect and respond to that hidden information, but also to ensure control of that capacity, to respect and protect the rights of users online.”

www.d2dcrc.com.au

No silver bullets

NOT ENOUGH, AND TOO much: that’s the core problem we face globally when it comes to energy and climate change. Demand for energy is booming: it’s forecast to rise 56% by 2040 from 2010 levels. More than 85% of this increase will come from countries outside the club of rich nations, the Organisation for Economic Cooperation and Development (OECD). Energy prices are rising, and there’s a race on to drill oil and gas fields, dig coal mines and build power plants. It’ll get even more frenzied beyond 2040 as India, Brazil and China ride the wealth curve higher.
But today, too much energy – 87% – comes from fossil fuels, energy sources that exacerbate climate change. Despite notable efforts to reduce emissions, fossil fuels will remain the dominant energy source: by 2040 renewables – like hydro, wind, solar and biomass – are forecast to contribute 15% to our coming needs, just four points up from 2010.
What to do? Ignoring the human contribution to climate change is one way to react, but reality has a habit of catching up with you: if 97% of peer-reviewed science says industrial activity is the cause, and that economically catastrophic changes will result, it’s a brave soul who bets otherwise. As astrophysicist Neil deGrasse Tyson recently quipped, “the good thing about science is that it’s true whether or not you believe in it”.
The problem with greenhouse gases is that they stay in the atmosphere for decades, even centuries, with new tonnage piling up on previous years’. And with demand booming, global policymakers are worried enough to consider the seemingly unthinkable: a shift away from fossil fuels entirely.
“To combat climate change, reducing emissions will simply not be enough – we need to eliminate them altogether,” said Ángel Gurría, secretary-general of the OECD, when handing down a new report in October 2013. “We need to achieve zero emissions from fossil fuel sources by the second half of the century.”
That’s a hell of a challenge.
In innovation terms, there are two ways forward: to boost efficiency and extract more energy from fossil fuels, thereby getting more bang per tonne of greenhouse gas emitted; or to commercialise zero-emission technologies.
It’s the latter where innovation is stuck in the narrow band of wind and solar, and advocates of these technologies do everyone a disservice by pretending they can meet all demand. In energy, there are no silver bullets.
In Canada recently, a brave band of scientists, engineers and policy specialists tackled this head-on. Could the world really move away from fossil fuels this century; would such a shift be possible, much less achievable? The answer entails planning technology pathways over a 60-year time-scale, and developing promising technologies.
“We hoped we would emerge with pragmatic next steps for a global energy transition,” says Jatin Nathwani, an engineering professor and energy specialist at Canada’s University of Waterloo, one of the scientific advisors.
The resulting report, Equinox Blueprint: Energy 2030, does just that.

It proposes five technological pathways: develop large-scale electricity storage for wind and solar plants, removing the problem of intermittent supply; explore enhanced geothermal deep drilling by creating 10 commercial-scale, 50 megawatt demonstration projects worldwide, run as public-private partnerships, which freely share knowledge (reducing the technical and financial risks for commercial players); accelerate and deploy organic photovoltaic technologies for the 1.5 billion people who live in off-grid communities; and pursue sustained research of advanced nuclear reactor designs – such as the Integral Fast Reactor – which offer inherent safety and allow most high-level radioactive waste to be ‘burned’ as energy is generated.

And finally, ‘smart urbanisation’: roll out 2000 new and existing ICT technologies – plus the larger-scale use of smart grids and superconductors for transmission and distribution in dense urban settings – to make cities more efficient and reduce emissions.
Where would the money come from? One source is suggested by the same OECD report: abandon the tax breaks OECD countries give to oil and gas producers, which are worth between US$55 billion and US$90 billion a year.

WilsondaSilvaWilson da Silva is the co-founder and former editor-in-chief of COSMOS science magazine, and he chaired the Equinox Summit: Energy 2030 meeting in Canada.

The spirit within

WE OFTEN HEAR CALLS for a more entrepreneurial culture. But what does that mean in practical terms? Yes, it is affected by our national psyche, outlook and attitude to risk. We hear that Australians don’t ‘embrace failure’, and that our finance sector is too conservative in its attitude to science and innovation. These opinions might be true, but regardless we also have to get the building blocks right.

The ‘next big thing’ might come from a series of small steps in developing the environment for more innovators and entrepreneurs to thrive. The government has just released an Industry Innovation and Competitiveness Agenda, which features a few of the steps that will improve the situation for entrepreneurs in Australia.

Issuing share options to employees is an important way of attracting talent. New companies have an idea, a prayer and not much cash. But brilliant young people are often willing to take shares or options in lieu of salaries for a year or two to join the startup entrepreneurial adventure. They might take a very low salary, or spend a year couch surfing or forgoing the benefits of deodorant.

The incredible stories of the likes of Twitter, Instagram, Facebook and the rest mean that by taking shares in lieu of salary they may strike it rich. In Australia, rules introduced in 2009 killed off this pathway by demanding that tax be paid on those shares immediately. The government has now fixed that issue.

Removing barriers is another important avenue to increase business competitiveness in Australia. Simple things like vaccine companies undergoing identical audits from different regulatory agencies draws cash – and focus – out of the business. The government has decided to have a serious go at lowering those barriers.

For the Treasurer’s coming tax review, the Minister for Industry has flagged two more innovations: crowd sourcing of equity finance, and patent boxes. Australia is slow on the equity issue, with the USA, the UK, Canada and New Zealand all ahead of us. But the government has received a very comprehensive report detailing the necessary changes, and action is expected soon. The patent box concept, which started in the UK, allows companies to isolate earnings from patents and have them favourably taxed.

Apart from government, financing of innovation is slowly improving. Westpac has provided $50 million to Reinventure, a venture capital company. CSIRO’s new CEO, Larry Marshall, is an Aussie with 25 years of venture capital experience. If the equity-financing model allows self-managed super funds to invest, then who knows the limits?

Firing up the entrepreneurial spirit in Australia is the next big thing. The foundations are quickly being laid – next we need the builders to come in. The gap year has become common after senior secondary school. Wouldn’t it be something to see a ‘growth year’, when graduates or postgraduates gave themselves a year to pursue an idea?

TonyPeacockKnowHow founder Tony Peacock is the CEO of the CRC Association and 2014 Monash University Churchill Fellow at The Winston Churchill Memorial Trust.

Eye for detail

FADING VISION

At age 40–45, if you find you have to hold a book further away to read it, you may have developed presbyopia: an ageing-related condition in which the eye’s ability to focus on near objects is reduced as its lens progressively stiffens. At this point in life, some people visit an optometrist for the first time. Suddenly they need glasses – and will for the rest of their lives.

If Dr Paul Erickson has his way, however, future generations may be heading straight to an ophthalmic surgeon to have a revolutionary ‘accommodating gel’ injected into their eyes.

FIELD LEADER

Originally from Pennsylvania, USA, Erickson has led the accommodating gel project since 2010 with significant funding from the Vision CRC. He is the CEO of Brien Holden Vision Pty Ltd and Adventus Technology Inc – companies through which Vision CRC participant the Brien Holden Vision Institute develops and commercialises its technologies.

DEFINING THE PROBLEM

The crystalline lenses in our eyes can adjust their focal length (or ‘accommodate’) by changing shape – bulging or flattening according to the tension in fibres that connect the lens to the circular muscle surrounding the lens capsule. It’s a very flexible lens, but it evolved for a species that lives to around 40 years old, Erickson explains.

“During a person’s life, the lens material loses its softness and flexibility, and at around age 40 the loss begins to accelerate,” he adds. “It reaches a point where it’s very difficult for the stiffer lens to change its shape in order to see at a normal reading distance.”

THE SOLUTION

The accommodating gel project aims to replace the stiff natural lens with a new lens made from a siloxane gel – a compound of silicone. First, the non-functioning natural lens would be extracted through a procedure similar to surgery for cataracts (lenses which have become opaque). Then, the gel would be injected into the transparent lens capsule.

Finding a suitable material to replace the lens has been a 20-year search, says Erickson. The requirements are stringent: it must be a moderately viscous liquid that can be injected, and it must polymerise into a soft, flexible gel. It also has to be biocompatible and, of course, transparent. Developed in Australia, the gel is being trialled in rabbits.

“We’re fine-tuning the properties,” says Erickson. “Over the next two to three years, we hope to move into animal models that more closely resemble humans, and then on to human subjects.”

TEAMWORK ADVANCES

Erickson’s team works with the prestigious Bascom Palmer Eye Institute in Florida, USA. The partnership has already led to improved medical microscopic imaging technology for use during the procedure, which could immediately benefit eye surgeons conducting cataract operations, Erickson says.

Rabbits’ viral expansion

The British colonies of the South Pacific called an inter-colonial commission in 1883 to consider matters of common interest. German and French intentions in the Pacific, quarantine and trade issues loomed large. So too did the rabbit, which less than 25 years after its introduction to Australia from Europe was considered “so serious a national evil” it could not be left “to the efforts of individuals for its remedy”.

200115_rabbits_box1 Within five years, Henry Parkes had sponsored an international competition offering the astounding sum of £25,000 to fix the problem. This sparked an ongoing quest for biological controls for Australia’s number one vertebrate pest. Where Louis Pasteur and others had tried and failed, the CSIRO succeeded, twice, with new viral controls: myxoma virus in the 1950s and rabbit haemorrhagic disease virus (RHDV, also known as rabbit calicivirus) in the 1990s. Myxoma received a boost in the 1960s when a new carrier for the virus, the European rabbit flea, was introduced.

The Invasive Animals CRC (IA CRC) is hoping to mirror that success with a new program aimed at improving the impact of RHDV. “When we brought RHDV to Australia, only one strain, a Czech strain, was available to us,” said Dr Brian Cooke, from the IA CRC and the University of Canberra, who has spent his career battling rabbits using biological controls.

“We now understand that another strain – RCV-A1, which doesn’t cause the disease – was already here. This immunises some rabbits, which is why RHDV was less effective in wetter, higher production areas where it is more prevalent. In arid Australia, generally without RCV-A1, around 85% of rabbits died.”

Under the RHD-Boost Program, the IA CRC searched the world for more effective RHDV strains, eventually importing and screening 38 naturally varying strains. After additional tests, six were further investigated, and two virus strains – both from South Korea – demonstrated advantages over the existing Czech strain. One also showed an ability to overcome the partial protection from the problematic RCV-A1 calicivirus.

200115_rabbits_box2 CEO of the CRC, Andreas Glanznig, said the discovery is encouraging but there are more steps to take before a new RHDV strain can be released. “Myxoma and RHDV are the only two examples of wide-scale viral biocontrol for vertebrate animals – ever.”

The rewards are “potentially huge”, he said. “These two viruses have so far delivered more than $70 billion in value to Australia and prevented untold environmental damage.” Myxoma still kills about half the rabbits born in Australia today, at zero cost.

With rabbit numbers on the rise, Australia needs to stay on the front foot. “It is imperative that we have a pipeline of new RHDV strains to keep rabbit biocontrol effective. The alternative will undo decades of management of Australia’s most costly vertebrate pest,” said Glanznig.

Tony Peacock

www.invasiveanimals.com